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Our goal is to discover principles of mitochondrial signal transduction and to study their role in the maintenance of human health, and in the development of disease.
We address this question by combining genetic and molecular manipulation of mitochondrial structure and functions, with imaging and systems biology approaches to capture and dissect meaningful patterns of (dys)regulation.
Our experimental systems include cellular, animal, and human disease models. We integrate knowledge from mitochondrial biology, neuroscience, social sciences, stress physiology, and mitochondrial medicine to understand organizing principles of mitochondrial communication and signal transduction. We then test the underlying mechanisms operating across levels of complexity − from organelle to organism.
We address this question by combining genetic and molecular manipulation of mitochondrial structure and functions, with imaging and systems biology approaches to capture and dissect meaningful patterns of (dys)regulation.
Our experimental systems include cellular, animal, and human disease models. We integrate knowledge from mitochondrial biology, neuroscience, social sciences, stress physiology, and mitochondrial medicine to understand organizing principles of mitochondrial communication and signal transduction. We then test the underlying mechanisms operating across levels of complexity − from organelle to organism.
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