Mitochondrial disease is a group of heterogenous disorders caused by inherited genetic defects in the mitochondrial and nuclear genomes.
We work to better understand how mitochondrial dysfunction alters different cell types, organ systems, and the communication between them. In particular, we focus on understanding how the organism perceives and responds to stress.
We use a transdisciplinary approach to dissect and understand the role of genetic, cellular, physiological, and psychosocial factors in disease onset and progression.
"Variability is the law of life, and as no two faces are the same, so no two bodies are alike, and no two individuals
react alike and behave alike under the abnormal conditions which we know as disease"
− Sir William Osler (1849-1919)
The MiSBIE Study
Mitochondrial Stress, Brain Imaging, and Epigenetics - The MiSBIE study aims to define the role of mitochondria in the regulation of multisystemic response to stress in humans, and to explore the underlying neural and epigenetic mechanisms. By studying patients with mtDNA disease, we aim to understand new mechanisms that contribute to mitochondrial disease onset and progression.
- Quantitative 3D mapping of the human skeletal muscle mitochondrial network
Vincent AE, White K, Davey T, Philips J, Ogden RT, Lawess C, Warren C, Hall MG, Ng YS, Falkous G, Holden T, Deehan D, Taylor RW, Turnbull DM, Picard M. Cell Rep 2019 (in press) PubMed PDF
- Sub-cellular origin of mtDNA deletions in human skeletal muscle
Vincent AE, Rosa HS, Pabis K, Lawless C, Grünewald A, Chen C, Rygiel KA, Rocha MC, Falkous G, Perissi V, White K, Davey T, Grady JP, Petrof B, Sayer AA, Cooper C, Taylor RW, Turnbull DM, Picard M. Annals Neurol 2018; 84(2):289-301 PubMed PDF
- The spectrum of mitochondrial ultrastructural defects in mitochondrial myopathy
Vincent AE, Ng YS, White K, Davey T, Mannella C, Falkous G, Feeney C, Schaefer AM, McFarland R, Gorman GS, Taylor RW,
Turnbull DM, Picard M. Sci Rep 2016; 6:30610 PubMed PDF Suppl
- Disentangling (epi)genetic and environmental contributions to the m.3243A>G MELAS mutation phenotype: Phenotypic destiny in mitochondrial disease?
Picard M, Hirano M. JAMA Neurol 2016; 73(8):923-5 PubMed PDF
- Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory and transcriptional responses to psychological stress
Picard M, McManus MJ, Gray J, Nasca C, Moffat C, Kopinsky P, Seifert E, McEwen BS, Wallace DC. PNAS 2015; 112(48):E6614-23 PubMed PDF