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Publications


Selected publications 

2020
  • Mitochondrial respiratory chain function modulates LPS-induced inflammatory signatures in human blood
    Karan KR, Trumpff C, McGill MA, Thomas  JE, Sturm G, Lauriola V, Sloan RP, Rohleder N, Kaufman BK, Marsland AL, Picard M. 
    Brain Behav Immun-Health 2020; 100080   PubMed   PDF​   Suppl

  • The social nature of mitochondria: Implications for human health
    Picard M, Sandi C. Neurosci Biobehav Rev 2020 (in press)   PubMed   PDF​

2019
  • Mitochondrial psychobiology: Foundation and applications
    Picard M, Trumpff C, Burelle Y. Curr Opin Behav Sci 2020;   PDF
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  • Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts
    Sturm G, Cardenas A, Bind MA, Horvath S, Wang S, Wang Y, Hägg S, Hirano M, Picard M. Epigenetics 201914(10):961-976   PubMed   PDF

  • Predictors of ccf-mtDNA reactivity to acute psychological stress identified using machine learning classifiers: A proof-of-concept
    Trumpff C, Marsland AL, Sloan RP, Kaufman BK, Picard M. Psychoneuroendocrinol 2019; 107:82-92   PubMed   PDF

  • Acute psychological stress increases serum circulating cell-free mitochondrial DNA
    Trumpff C, Marsland AL, Basualto C, Martin JL, Carroll JE, Sturm G, Gu Z, Vincent A, Kaufman BA, Picard M. Psychoneuroendocrinol 2019; 106:268-276     PubMed   PDF
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  • Accelerating research on biological aging and mental health: Current challenges and future directions
    Han LKM, Verhoeven JE, Tyrka A, Penninx BWJH, Wolkowitz OM, Månsson KNT, Lindqvist D, Vinkers CH, Boks MP, Révész D, Mellon SH, Picard M. Psychoneuroendocrinol 2019; 106:293-311   PubMed   PDF
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  • Quantitative 3D mapping of the human skeletal muscle mitochondrial network
    Vincent AE,  White K,  Davey T, Philips J, Ogden RT,  Lawess C,  Warren C,  Hall MG,  Ng YS,  Falkous G,  Holden T, Deehan D, Taylor RW,  Turnbull DM,  Picard M.  Cell Rep 2019; 26(4):996-1009    PubMed   PDF

2018
  • Sub-cellular origin of mtDNA deletions in human skeletal muscle
    Vincent AE, Rosa HS, Pabis K, Lawless C, Grünewald A, Chen C, Rygiel KA, Rocha MC, Falkous G, Perissi V, White K, Davey T, Grady JP, Petrof B, Sayer AA, Cooper C, Taylor RW, Turnbull DM, Picard M.  Annals Neurol 2018; 84(2):289-301    PubMed   PDF​

  • Multilevel heterogeneity of mitochondrial respiratory chain deficiency
    Vincent AE, Picard M. J Pathol 2018; 246:261–265   PubMed   PDF

  • Mitochondrial dynamics in adaptive and maladaptive cellular stress responses
    Eisner V, Picard M, Hajnoczky G. Nat Cell Biol 2018; 20(7):655-665   PubMed   PDF​

  • A mitochondrial health index sensitive to mood and caregiver stress
    Picard M, Prather AA, Puterman E, Cuillerier A, Coccia M, Aschbacher K, Burelle Y, Epel ES. Biol Psychiatr 2018; 84(1):9-17   ​PubMed   PDF​

  • Psychological stress and mitochondria: A systematic review (Part I)
    Picard M, McEwen BS. Psychosom Med 2018; 80(2):141-153   PubMed   PDF
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  • Psychological stress and mitochondria: A conceptual framework (Part II)
    Picard M, McEwen BS. Psychosom Med 2018; 80(2):126-140   PubMed   PDF

  • Major depressive disorder is associated with elevated levels of circulating cell-free mitochondrial DNA, but not of leukocytes mitochondrial DNA copy number
    Lindqvist D, Wolkowitz OM, Picard M, Ohlsson L, Bersani FS, Fernström J, Westrin A, Hough CM, Lin J, Reus VI, Epel ES, Mellon SH. Neuropsychopharmacol 2018; 43(7):1557-1564    PubMed
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  • An energetic view of stress: Focus on mitochondria
    Picard M, McEwen BS, Epel ES, Sandi C. Front Neuroendocrinol2018; 49:72-85 PubMed   PDF​
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2017
  • Mitochondrial nanotunnels
    Vincent AE, Turnbull DM, Hajnoczky G, Eisner V, Picard M. Trends Cell Biol 2017; 27(11):787-799   PubMed   PDF   Suppl

  • Independent impacts of aging on mitochondrial DNA quantity and quality in humans
    Zhang R, Wang Y, Ye K, Picard M, Gu Z.  BMC Genomics 2017; 18:890   PubMed

  • Mitochondrial nexus to allostatic load biomarkers
    Picard M, Juster RP, Sloan RP, McEwen BS. Psychosom Med 2017; 79(1):114-117   PubMed   PDF

  • Mitochondrial energy deficiency signals hyperproliferation of skeletal muscle mitochondria and enhanced insulin sensitivity
    Morrow RM, Picard M, Derbeneva O, Leipzig J, McManus MJ, Gouspillou G, Barbat-Artigas S, Hepple RT, Murdock DG, Wallace DC. PNAS 2017 (in press)     PubMed   PDF​

  • Depression, telomeres and mitochondrial DNA: between-person and within-person associations from a 10-year longitudinal study
    Verhoeven JE, Révész D, Picard M, Epel EE, Wolfowitz OM, Matthews KA, Penninx BWJH, Puterman E. Mol Psychiatry 2017 (in press)   PubMed

2016
  • The rise of mitochondria in medicine
    ​
    Picard M, Wallace DC, Burelle Y. Mitochondrion 2016; 30:105-16   PubMed   PDF
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  • The spectrum of mitochondrial ultrastructural defects in mitochondrial myopathy
    Vincent AE, Ng YS, White K, Davey T, Mannella C, Falkous G, Feeney C, Schaefer AM, McFarland R, Gorman GS, Taylor RW, 
    Turnbull DM, Picard M. Sci Rep 2016; 6:30610    PubMed   PDF   Suppl

  • Genetic evidence for elevated pathogenicity of mitochondrial DNA heteroplasmy in autism spectrum disorder
    Wang Y, Picard M, Gu Z. Plos Genet 2016; 12(10):e1006391    PubMed   PDF
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  • Allostatic load and comorbidities: A mitochondrial, neuroepigenetic, and psychoevolutionary perspective
    Juster RP, Russell JJ, Almeidac D, Picard M. Dev Psychopathol 2016; 28(4pt1):1117:46   PubMed   PDF

  • Multimorbidity as the manifestation of network disturbances
    Sturmberg JP, Bennett J, Picard M, Martin C. J Eval Clin Pract 2017; 23(1):199-208      PubMed

  • Expanding our understanding of mtDNA deletions
    Picard M, Vincent AE, Turnbull DM. Cell Metab 2016; 24(1):3-4   PubMed​​   PDF

  • Disentangling (epi)genetic and environmental contributions to the m.3243A>G MELAS mutation phenotype: Phenotypic destiny in mitochondrial disease?
    Picard M, Hirano M. JAMA Neurol 2016; 73(8):923-5   PubMed   PDF

  • Mitochondrial DNA depletion in respiratory chain-deficient Parkinson disease neurons
    Grüenewald A, Rygiel KA, Hepplewhite PD, Morris C, Picard M, Turnbull DM. Ann Neurol 2016; 79(3):366-78   PubMed   PDF

  • The ageing neuromuscular system and sarcopenia: A mitochondrial perspective
    Rygiel KA, Picard M, Turnbull DM. J Physiol 2016;
    594(16): 4499–512   PubMed   PDF

​2015
  • Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory and transcriptional responses to psychological stress
    Picard M, McManus MJ, Gray J, Nasca C, Moffat C, Kopinsky P, Seifert E, McEwen BS, Wallace DC. PNAS 2015; 112(48):E6614-23  PubMed   
    PDF

  • Mitochondrial synapses: Intracellular communication and signal integration
    Picard M. 
    Trends Neurosci 2015; 38(8):468-474   PubMed   PDF

  • Inter-mitochondrial coordination of cristae at regulated membrane junctions
    Picard M, McManus MJ, Csordas G, Varnai P, Dorn GW, Williams D, Hajnoczky G, Wallace DC. Nat Commun 2015; 6:6259  
    ​PubMed   
    PDF
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  • Mitochondrial signaling in neurodegeneration 
    Picard M, McManus MJ. In Reeve AK, Simcox A, Duchen MR, Turnbull DM. (Eds.) Mitochondrial dysfunction in neurodegenerative disorders, 2nd edition, London: Springer (2016)   Link
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  • Mitochondrial morphology is altered in atrophied skeletal muscle of aged mice
    Leduc-Gaudet JP, Picard M, St-Jean Pelletier F, Sgarioto N, Auger MJ, Robitaille R, St-Pierre DH, Gouspillou G. Oncotarget 2015; 6(20):17923-17937   PubMed   
    PDF

  • Mechanical ventilation triggers abnormal mitochondrial dynamics and morphology in the diaphragm
    Picard M, Azuelos I, Jung B, Giordano C, Matecki S, Hussain SNA, White K, Li T, Liang F, Benedetti A, Gentil BJ, Burelle Y, Petrof B.
    J Appl Physiol 2015; 118(9):1161-1171   PubMed   
    PDF
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2014
  • Mitochondrial allostatic load puts the ‘gluc’ back into glucocorticoids
    Picard M, Juster RP, McEwen BS. 
    Nat Rev Endocrinol 2014; 10(5):303-10   PubMed   PDF

  • Progressive increase in mtDNA 3243A>G heteroplasmy results in abrupt transcriptional remodeling
    Picard M, Zhang J, Hanecock S, Derbeneva O, Golhar R, Golik P, O’Hearn S, Levy SE, Potluri P, Lvova M, Davila A, Lin CS, Perin JC, Rappaport EF, Hakonarson H, Trounce I, Procaccio V, Wallace DC. PNAS 2014; 111(38):E4033;4042   PubMed   
    PDF

  • Mitochondria impact brain function and cognition
    Picard M and McEwen BS. PNAS 2014; 111(1):7-8 [Commentary]   PubMed   PDF
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2013
  • Acute exercise remodels mitochondrial membrane interactions in mouse skeletal muscle
    Picard M, Gentil B, McManus MJ, StLouis K, White K, Gartside S, Wallace DC, Turnbull DM.
    J Appl Physiol 2013; 115(10):1562-71   PubMed   PDF

  • Allostatic load as a tool for monitoring comorbidities in schizophrenia and bipolar disorder
    Bizik G, Picard M, Nijjer R, Tourjman V, McEwen BS, Lupien SJ, Juster RP. Harv Rev Neurosci 2013; 21(6):296-313   PubMed   
    PDF

  • Linking metabolic state and mitochondrial DNA in chronic disease, health and aging
    Picard M, Turnbull DM. Diabetes 2013; 62(3):672-8   PubMed   
    PDF

  • Mitochondrial morphology transitions and functions: Implications for retrograde signaling?
    Picard M, Shirihai O, Gentil BJ, Burelle Y. Am J Physiol Regul Integr Comp Physiol 2013; 304:R393-406   PubMed   
    PDF

  • Mitochondrial morphology, topology and membrane interactions in skeletal muscle: A three-dimensional electron microscopy study.
    Picard M, White K, Turnbull DM. J Appl Physiol 2013; 114(2):161-71   PubMed    
    PDF

2012 and earlier
  • Mitochondrial dysfunction and lipid accumulation in the human diaphragm during mechanical ventilation
    Picard M, Jung B, Liang F, Azuelos I, Hussain SNA, Goldberg P, Godin R, Danialou G, Chaturvedi R, Rygiel K, Matecki S, Jaber S, Des Rosiers C, Karpati G, Ferri L, Burelle Y, Turnbull DM, Taivassalo T, Petrof BJ. Am J Resp Crit Care Med 2012; 186(11):1140-9   PubMed      
    PDF

  • Mitochondria: Starving to reach quorum?
    Picard M and Burelle Y. Bioessays 2012; 43(4):272-4   PubMed   
    PDF

  • Mitochondrial specialization in glycolytic and oxidative muscle fibers: Tailoring the organelle for optimal function
    Picard M, Hepple RT, Burelle Y. Am J Physiol Cell Physiol 2012; 302(4):C629-41   PubMed   
    PDF
 
  • Pathways to aging: The mitochondrion at the intersection of biological and psychosocial sciences
    Picard M. J Aging Res 2011; 814096:1-11   PubMed   
    PDF

  • Mitochondria: Isolation, structure and function
    Picard M, Taivassalo T, Gouspillou G, Hepple RT. J Physiol (London) 2011; 589(18):4413-21   PubMed   
    PDF

  • A transdisciplinary perspective of chronic stress in relation to psychopathology throughout lifespan development
    Juster RP, Bizik G, Picard M, Arsenault-Lapierre G, Sindi S, Trepanier L, Marin MF, Wan N, Sekerovic Z, Lord C, Fiocco A, Plusquellec P, McEwen B, Lupien S. Dev Psychopathol 2011; 23(03):725-76    PubMed   
    PDF

  • Mitochondrial structure and function are disrupted by standard isolation methods
    Picard M, Taivassalo T, Ritchie D, Wright KJ, Thomas MM, Romestaing C, Hepple RT. PLoS One 2011; 6(3):e18317   PubMed    
    PDF

  • The need for a transdisciplinary, global health framework
    Picard M, Sabiston C, McNamara JK. J Alt Complement Med 2011; 17(2):179-84   PubMed   
    PDF
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  • Mitochondrial functional impairment with aging is exaggerated in isolated mitochondria compared to permeabilized myofibers
    Picard M, Ritchie D, Wright KJ, Romestaing C, Thomas MM, Rowan SL, Taivassalo T, Hepple RT. Aging Cell 2010; 9:1032-46   PubMed    
    PDF
    ​
Complete list of publications

Updated: May  2020
  • Home
  • Research
    • Mitochondrial Signaling & Aging
    • Stress Psychophysiology and Allostatic Load
    • Mitochondrial Disease & the Brain
    • Techniques and Resources >
      • Protocols
  • Publications
  • Members
    • Lab Pictures
    • Lab Alumni
  • DATA
  • Contact