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Selected publications
2019
2018
2016
2015
2012 and earlier
Updated: June 2019
2019
- Mitochondrial psychobiology: Foundation and applications
Picard M, Trumpff C, Burelle Y. Curr Opin Behav Sci (in press) PDF
- Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts
Sturm G, Cardenas A, Bind MA, Horvath S, Wang S, Wang Y, Hägg S, Hirano M, Picard M. Epigenetics 2019 (in press) PubMed PDF - Predictors of ccf-mtDNA reactivity to acute psychological stress identified using machine learning classifiers: A proof-of-concept
Trumpff C, Marsland AL, Sloan RP, Kaufman BK, Picard M. Psychoneuroendocrinol 2019; 107:82-92 PubMed PDF - Acute psychological stress increases serum circulating cell-free mitochondrial DNA
Trumpff C, Marsland AL, Basualto C, Martin JL, Carroll JE, Sturm G, Gu Z, Vincent A, Kaufman BA, Picard M. Psychoneuroendocrinol 2019; 106:268-276 PubMed PDF
- Accelerating research on biological aging and mental health: Current challenges and future directions
Han LKM, Verhoeven JE, Tyrka A, Penninx BWJH, Wolkowitz OM, Månsson KNT, Lindqvist D, Vinkers CH, Boks MP, Révész D, Mellon SH, Picard M. Psychoneuroendocrinol 2019; 106:293-311 PubMed PDF
- Quantitative 3D mapping of the human skeletal muscle mitochondrial network
Vincent AE, White K, Davey T, Philips J, Ogden RT, Lawess C, Warren C, Hall MG, Ng YS, Falkous G, Holden T, Deehan D, Taylor RW, Turnbull DM, Picard M. Cell Rep 2019 (in press) PubMed PDF
2018
- Sub-cellular origin of mtDNA deletions in human skeletal muscle
Vincent AE, Rosa HS, Pabis K, Lawless C, Grünewald A, Chen C, Rygiel KA, Rocha MC, Falkous G, Perissi V, White K, Davey T, Grady JP, Petrof B, Sayer AA, Cooper C, Taylor RW, Turnbull DM, Picard M. Annals Neurol 2018; 84(2):289-301 PubMed PDF - Multilevel heterogeneity of mitochondrial respiratory chain deficiency
Vincent AE, Picard M. J Pathol 2018; 246:261–265 PubMed PDF - Mitochondrial dynamics in adaptive and maladaptive cellular stress responses
Eisner V, Picard M, Hajnoczky G. Nat Cell Biol 2018; 20(7):655-665 PubMed PDF - A mitochondrial health index sensitive to mood and caregiver stress
Picard M, Prather AA, Puterman E, Cuillerier A, Coccia M, Aschbacher K, Burelle Y, Epel ES. Biol Psychiatr 2018; 84(1):9-17 PubMed PDF - Psychological stress and mitochondria: A systematic review (Part I)
Picard M, McEwen BS. Psychosom Med 2018; 80(2):141-153 PubMed PDF
- Psychological stress and mitochondria: A conceptual framework (Part II)
Picard M, McEwen BS. Psychosom Med 2018; 80(2):126-140 PubMed PDF - Major depressive disorder is associated with elevated levels of circulating cell-free mitochondrial DNA, but not of leukocytes mitochondrial DNA copy number
Lindqvist D, Wolkowitz OM, Picard M, Ohlsson L, Bersani FS, Fernström J, Westrin A, Hough CM, Lin J, Reus VI, Epel ES, Mellon SH. Neuropsychopharmacol 2018; 43(7):1557-1564 PubMed
- An energetic view of stress: Focus on mitochondria
Picard M, McEwen BS, Epel ES, Sandi C. Front Neuroendocrinol2018; 49:72-85 PubMed PDF
- Mitochondrial nanotunnels
Vincent AE, Turnbull DM, Hajnoczky G, Eisner V, Picard M. Trends Cell Biol 2017; 27(11):787-799 PubMed PDF Suppl - Independent impacts of aging on mitochondrial DNA quantity and quality in humans
Zhang R, Wang Y, Ye K, Picard M, Gu Z. BMC Genomics 2017; 18:890 PubMed - Mitochondrial nexus to allostatic load biomarkers
Picard M, Juster RP, Sloan RP, McEwen BS. Psychosom Med 2017; 79(1):114-117 PubMed PDF - Mitochondrial energy deficiency signals hyperproliferation of skeletal muscle mitochondria and enhanced insulin sensitivity
Morrow RM, Picard M, Derbeneva O, Leipzig J, McManus MJ, Gouspillou G, Barbat-Artigas S, Hepple RT, Murdock DG, Wallace DC. PNAS 2017 (in press) PubMed PDF - Depression, telomeres and mitochondrial DNA: between-person and within-person associations from a 10-year longitudinal study
Verhoeven JE, Révész D, Picard M, Epel EE, Wolfowitz OM, Matthews KA, Penninx BWJH, Puterman E. Mol Psychiatry 2017 (in press) PubMed
2016
- The rise of mitochondria in medicine
Picard M, Wallace DC, Burelle Y. Mitochondrion 2016; 30:105-16 PubMed PDF
- The spectrum of mitochondrial ultrastructural defects in mitochondrial myopathy
Vincent AE, Ng YS, White K, Davey T, Mannella C, Falkous G, Feeney C, Schaefer AM, McFarland R, Gorman GS, Taylor RW,
Turnbull DM, Picard M. Sci Rep 2016; 6:30610 PubMed PDF Suppl - Genetic evidence for elevated pathogenicity of mitochondrial DNA heteroplasmy in autism spectrum disorder
Wang Y, Picard M, Gu Z. Plos Genet 2016; 12(10):e1006391 PubMed PDF
- Allostatic load and comorbidities: A mitochondrial, neuroepigenetic, and psychoevolutionary perspective
Juster RP, Russell JJ, Almeidac D, Picard M. Dev Psychopathol 2016; 28(4pt1):1117:46 PubMed PDF - Multimorbidity as the manifestation of network disturbances
Sturmberg JP, Bennett J, Picard M, Martin C. J Eval Clin Pract 2017; 23(1):199-208 PubMed - Expanding our understanding of mtDNA deletions
Picard M, Vincent AE, Turnbull DM. Cell Metab 2016; 24(1):3-4 PubMed PDF - Disentangling (epi)genetic and environmental contributions to the m.3243A>G MELAS mutation phenotype: Phenotypic destiny in mitochondrial disease?
Picard M, Hirano M. JAMA Neurol 2016; 73(8):923-5 PubMed PDF - Mitochondrial DNA depletion in respiratory chain-deficient Parkinson disease neurons
Grüenewald A, Rygiel KA, Hepplewhite PD, Morris C, Picard M, Turnbull DM. Ann Neurol 2016; 79(3):366-78 PubMed PDF - The ageing neuromuscular system and sarcopenia: A mitochondrial perspective
Rygiel KA, Picard M, Turnbull DM. J Physiol 2016; 594(16): 4499–512 PubMed PDF
2015
- Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory and transcriptional responses to psychological stress
Picard M, McManus MJ, Gray J, Nasca C, Moffat C, Kopinsky P, Seifert E, McEwen BS, Wallace DC. PNAS 2015; 112(48):E6614-23 PubMed PDF - Mitochondrial synapses: Intracellular communication and signal integration
Picard M. Trends Neurosci 2015; 38(8):468-474 PubMed PDF - Inter-mitochondrial coordination of cristae at regulated membrane junctions
Picard M, McManus MJ, Csordas G, Varnai P, Dorn GW, Williams D, Hajnoczky G, Wallace DC. Nat Commun 2015; 6:6259
PubMed PDF
- Mitochondrial signaling in neurodegeneration
Picard M, McManus MJ. In Reeve AK, Simcox A, Duchen MR, Turnbull DM. (Eds.) Mitochondrial dysfunction in neurodegenerative disorders, 2nd edition, London: Springer (2016) Link
- Mitochondrial morphology is altered in atrophied skeletal muscle of aged mice
Leduc-Gaudet JP, Picard M, St-Jean Pelletier F, Sgarioto N, Auger MJ, Robitaille R, St-Pierre DH, Gouspillou G. Oncotarget 2015; 6(20):17923-17937 PubMed PDF - Mechanical ventilation triggers abnormal mitochondrial dynamics and morphology in the diaphragm
Picard M, Azuelos I, Jung B, Giordano C, Matecki S, Hussain SNA, White K, Li T, Liang F, Benedetti A, Gentil BJ, Burelle Y, Petrof B.
J Appl Physiol 2015; 118(9):1161-1171 PubMed PDF
- Mitochondrial allostatic load puts the ‘gluc’ back into glucocorticoids
Picard M, Juster RP, McEwen BS. Nat Rev Endocrinol 2014; 10(5):303-10 PubMed PDF - Progressive increase in mtDNA 3243A>G heteroplasmy results in abrupt transcriptional remodeling
Picard M, Zhang J, Hanecock S, Derbeneva O, Golhar R, Golik P, O’Hearn S, Levy SE, Potluri P, Lvova M, Davila A, Lin CS, Perin JC, Rappaport EF, Hakonarson H, Trounce I, Procaccio V, Wallace DC. PNAS 2014; 111(38):E4033;4042 PubMed PDF - Mitochondria impact brain function and cognition
Picard M and McEwen BS. PNAS 2014; 111(1):7-8 [Commentary] PubMed PDF
- Acute exercise remodels mitochondrial membrane interactions in mouse skeletal muscle
Picard M, Gentil B, McManus MJ, StLouis K, White K, Gartside S, Wallace DC, Turnbull DM. J Appl Physiol 2013; 115(10):1562-71 PubMed PDF - Allostatic load as a tool for monitoring comorbidities in schizophrenia and bipolar disorder
Bizik G, Picard M, Nijjer R, Tourjman V, McEwen BS, Lupien SJ, Juster RP. Harv Rev Neurosci 2013; 21(6):296-313 PubMed PDF - Linking metabolic state and mitochondrial DNA in chronic disease, health and aging
Picard M, Turnbull DM. Diabetes 2013; 62(3):672-8 PubMed PDF - Mitochondrial morphology transitions and functions: Implications for retrograde signaling?
Picard M, Shirihai O, Gentil BJ, Burelle Y. Am J Physiol Regul Integr Comp Physiol 2013; 304:R393-406 PubMed PDF - Mitochondrial morphology, topology and membrane interactions in skeletal muscle: A three-dimensional electron microscopy study.
Picard M, White K, Turnbull DM. J Appl Physiol 2013; 114(2):161-71 PubMed PDF
2012 and earlier
- Mitochondrial dysfunction and lipid accumulation in the human diaphragm during mechanical ventilation
Picard M, Jung B, Liang F, Azuelos I, Hussain SNA, Goldberg P, Godin R, Danialou G, Chaturvedi R, Rygiel K, Matecki S, Jaber S, Des Rosiers C, Karpati G, Ferri L, Burelle Y, Turnbull DM, Taivassalo T, Petrof BJ. Am J Resp Crit Care Med 2012; 186(11):1140-9 PubMed PDF - Mitochondria: Starving to reach quorum?
Picard M and Burelle Y. Bioessays 2012; 43(4):272-4 PubMed PDF - Mitochondrial specialization in glycolytic and oxidative muscle fibers: Tailoring the organelle for optimal function
Picard M, Hepple RT, Burelle Y. Am J Physiol Cell Physiol 2012; 302(4):C629-41 PubMed PDF
- Pathways to aging: The mitochondrion at the intersection of biological and psychosocial sciences
Picard M. J Aging Res 2011; 814096:1-11 PubMed PDF - Mitochondria: Isolation, structure and function
Picard M, Taivassalo T, Gouspillou G, Hepple RT. J Physiol (London) 2011; 589(18):4413-21 PubMed PDF - A transdisciplinary perspective of chronic stress in relation to psychopathology throughout lifespan development
Juster RP, Bizik G, Picard M, Arsenault-Lapierre G, Sindi S, Trepanier L, Marin MF, Wan N, Sekerovic Z, Lord C, Fiocco A, Plusquellec P, McEwen B, Lupien S. Dev Psychopathol 2011; 23(03):725-76 PubMed PDF - Mitochondrial structure and function are disrupted by standard isolation methods
Picard M, Taivassalo T, Ritchie D, Wright KJ, Thomas MM, Romestaing C, Hepple RT. PLoS One 2011; 6(3):e18317 PubMed PDF - The need for a transdisciplinary, global health framework
Picard M, Sabiston C, McNamara JK. J Alt Complement Med 2011; 17(2):179-84 PubMed PDF
- Mitochondrial functional impairment with aging is exaggerated in isolated mitochondria compared to permeabilized myofibers
Picard M, Ritchie D, Wright KJ, Romestaing C, Thomas MM, Rowan SL, Taivassalo T, Hepple RT. Aging Cell 2010; 9:1032-46 PubMed PDF
Updated: June 2019