PREPRINTS
  • Chronic glucocorticoid stress reveals increased energy expenditure and accelerated aging as cellular features of
    allostatic load
    Bobba-Alves N,  Sturm G, Lin J, Ware SA,  Karan KR,  Monzel AS,   Bris C,  Procaccio V,  Lenaers G,  Higgins-Chen A,  Levine M,  Horvath S, Santhanam BS,  Kaufman BA,  Hirano M, Epel E,  Picard M. 
    Preprint: www.biorxiv.org/content/10.1101/2022.02.22.481548v2
    ​

2023
  • Multifaceted mitochondria: Moving mitochondrial science beyond function and dysfunction
    Monzel AS, Enriques JA, Picard M. Nat Metab 2023 ​  Link  PDF

  • OxPhos defects cause hypermetabolism and reduce lifespan in cells and patients with mitochondrial diseases
    Sturm G, Karan KR, Monzel AS, Santhanam BS, Taivassalo T, Bris C, Duplaga SA, Cross M, Towheed A, Higgins-Chen A, McManus MJ, Cardenas A, Lin J, Epel ES, Rahman S, Vissing V, Grassi B, Levine M, Horvath S, Haller RG, Lanaers G, Wallace DC, Tavazoie S, Procaccio V, Kaufman BA, Seifert EL, Hirano H, Picard M. Commun Biol Link  PDF
2022
  • Mitochondrial signal transduction
    Picard M, Shirihai OS. Cell Metabolism  2022  Link PDF

  • A multi-omic and bioenergetics longitudinal aging dataset in primary human fibroblasts with mitochondrial perturbations
    Sturm G, Monzel AS, Karan KR, Michelson J, Ware SA, Cardenas A, Lin J, Bris C, Santhanam B, Murphy MP, Levine ME, Horvath S,
    Belsky D, Wang S, Procaccio V, Kaufman BA, Hirano M, Picard M. Sci Data  Link  PDF
    ​
  • The energetic cost of allostatic load
    Bobba-Alves N, Juster RP, Picard M. Psychoneuroendocrinology Volume 146 2022 Link PDF

  • Dynamic behavior of cell-free mitochondrial DNA in human saliva
    Trumpff C, Rausser S, Haahr R,  Karan KR, Gouspillou G, Putterman E, Kirschbaum C, Picard M. Psychoneuroendocrinology 
    ​Volume 143 2022     Link PDF

  • Mitochondrial respiratory chain protein co-regulation in the human brain
    Trumpff C, Owusu-Ansah E, Klein H, Lee A, Petyuk V, Wingo TS, Wingo AP, Thambisetty M, Ferrucci L, Seyfried NT, Bennett DA, ​De Jager PL, Picard M. Heliyon 2022  Link  PDF

  • Leukocyte cytokine responses in adult patients with mitochondrial DNA defects
    Karan KR, Trumpff C, Cross M, Englestad KM, Marsland AL, McGuire P, Hirano M, Picard M. J Mol Med  Link  PDF 

  • Why do we care more about disease than health?
    Picard M. Phenomics 2022;  Link PDF 

  • Human studies of mitochondrial biology demonstrate an overall lack of binary sex differences: A multivariate meta-analysis
    Junker A, Wang J, Gouspillou G, Ehinger JK, Elmér E, Sjövall F, Fisher-Wellman K, Neufer PD, Molina AJA, Ferrucci L, Picard M.
    FASEB J 2022; 36:e22146  Link   PDF

  • Integrating sex and gender in mitochondrial science
    Junker A, Juster RP, Picard M. Curr Opin Physiol 2022   Link  PDF

  • Energy transduction and the mind-mitochondria connection
    Picard M. The Biochemist  2022 44 (4): 14–18. Link PD

2021
  • Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures
    Rausser S, Trumpff C, McGill MA, Junker A, Wang W, Ho S, Mitchell A, Karan K, Monk C, Segerstrom S, Reed R, Picard M.
    eLife 2021; 10:e70899   PubMed  PDF 

  • Mitochondrial DNA quantity and quality in the human aged and Alzheimer’s disease brain.
    Klein H, Trumpff C, Yang HS, Lee AJ, Picard M, Bennett DA, De Jager. Mol Neurodegener 2021;16:75   PubMed   PDF

  • Quantitative mapping of human hair graying and reversal in relation to life stress
    Rosenberg A, Rausser S, Ren J, Mosharov EV, Sturm G, Ogden RT, Patel P, Soni RK, Lacefield C, Tobin DJ, Paus R, Picard M. 
    eLife 2021; 10:e67437   PubMed   PDF​   eLife Digest

  • 3D neuronal mitochondrial morphology in axons, dendrites, and cell bodies of the aging mouse hippocampus.
    Faitg J, Lacefied C, Davey T, White K, Laws R, Kosmidi S, Reeve AK, Kandel E, Vincent AE, Picard M. Cell Rep 2021; 36(6): 109509 PubMed   PDF

  • Stress and circulating cell-free mitochondrial DNA: a systematic review of human studies, physiological considerations, and technical recommendations.
    Trumpff C, Michelson J, Lagranha CJ, Taleon V, Karan K, Sturm G, Lindqvist D, Fernström J, Moser D, Kaufman BA, Picard M.
    Mitochondrion 59:225-245   PubMed   PDF​   Protocol

  • Mitochondria in epithelial ovarian carcinoma exhibit abnormal phenotypes and blunted associations with biobehavioral factors
    Bindra S, McGill MA, Triplett MK, Tyagi A, Thaker PH, Dahmoush L, Goodheart MJ, Ogden RT, E Owusu-Ansah, Karan KR, Cole S, Sood AK, Lutgendorf SK, Picard M. Sci Rep 2021; 11:11595   PubMed   PDF​

  • Blood mtDNA copy number: What are we counting?
    Picard M. Mitochondrion 2021 Link PDF​

  • The social nature of mitochondria: Implications for human health
    Picard M, Sandi C. Neurosci Biobehav Rev 2021; 120(5):595-610   PubMed   PDF​

2020
  • Mitochondrial respiratory chain function modulates LPS-induced inflammatory signatures in human blood
    Karan KR, Trumpff C, McGill MA, Thomas  JE, Sturm G, Lauriola V, Sloan RP, Rohleder N, Kaufman BK, Marsland AL, Picard M. 
    Brain Behav Immun-Health 2020; 100080   PubMed   PDF​   Suppl

​2019
  • Mitochondrial psychobiology: Foundation and applications
    Picard M, Trumpff C, Burelle Y. Curr Opin Behav Sci 2019; Link  PDF
    ​
  • Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts
    Sturm G, Cardenas A, Bind MA, Horvath S, Wang S, Wang Y, Hägg S, Hirano M, Picard M. Epigenetics 201914(10):961-976   PubMed   PDF

  • Predictors of ccf-mtDNA reactivity to acute psychological stress identified using machine learning classifiers: A proof-of-concept
    Trumpff C, Marsland AL, Sloan RP, Kaufman BK, Picard M. Psychoneuroendocrinol 2019; 107:82-92   PubMed   PDF

  • Acute psychological stress increases serum circulating cell-free mitochondrial DNA
    Trumpff C, Marsland AL, Basualto C, Martin JL, Carroll JE, Sturm G, Gu Z, Vincent A, Kaufman BA, Picard M. Psychoneuroendocrinol 2019; 106:268-276     PubMed   PDF
    ​
  • Accelerating research on biological aging and mental health: Current challenges and future directions
    Han LKM, Verhoeven JE, Tyrka A, Penninx BWJH, Wolkowitz OM, Månsson KNT, Lindqvist D, Vinkers CH, Boks MP, Révész D, Mellon SH, Picard M. Psychoneuroendocrinol 2019; 106:293-311   PubMed   PDF
    ​    ​
  • Quantitative 3D mapping of the human skeletal muscle mitochondrial network
    Vincent AE,  White K,  Davey T, Philips J, Ogden RT,  Lawess C,  Warren C,  Hall MG,  Ng YS,  Falkous G,  Holden T, Deehan D, Taylor RW,  Turnbull DM,  Picard M.  Cell Rep 2019; 26(4):996-1009    PubMed   PDF

2018
  • Sub-cellular origin of mtDNA deletions in human skeletal muscle
    Vincent AE, Rosa HS, Pabis K, Lawless C, Grünewald A, Chen C, Rygiel KA, Rocha MC, Falkous G, Perissi V, White K, Davey T, Grady JP, Petrof B, Sayer AA, Cooper C, Taylor RW, Turnbull DM, Picard M.  Annals Neurol 2018; 84(2):289-301    PubMed   PDF​
  • Mitochondrial dynamics in adaptive and maladaptive cellular stress responses
    Eisner V, Picard M, Hajnoczky G. Nat Cell Biol 2018; 20(7):655-665   PubMed   PDF​

  • A mitochondrial health index sensitive to mood and caregiver stress
    Picard M, Prather AA, Puterman E, Cuillerier A, Coccia M, Aschbacher K, Burelle Y, Epel ES. Biol Psychiatr 2018; 84(1):9-17   ​PubMed   PDF​

  • Psychological stress and mitochondria: A systematic review (Part I)
    Picard M, McEwen BS. Psychosom Med 2018; 80(2):141-153   PubMed   PDF
    ​
  • Psychological stress and mitochondria: A conceptual framework (Part II)
    Picard M, McEwen BS. Psychosom Med 2018; 80(2):126-140   PubMed   PDF
  • An energetic view of stress: Focus on mitochondria
    Picard M, McEwen BS, Epel ES, Sandi C. Front Neuroendocrinol2018; 49:72-85 PubMed   PDF​
    ​
2017
  • Mitochondrial nanotunnels
    Vincent AE, Turnbull DM, Hajnoczky G, Eisner V, Picard M. Trends Cell Biol 2017; 27(11):787-799   PubMed   PDF   Suppl

  • Independent impacts of aging on mitochondrial DNA quantity and quality in humans
    Zhang R, Wang Y, Ye K, Picard M, Gu Z.  BMC Genomics 2017; 18:890   PubMed

  • Mitochondrial nexus to allostatic load biomarkers
    Picard M, Juster RP, Sloan RP, McEwen BS. Psychosom Med 2017; 79(1):114-117   PubMed   PD

2016
  • The rise of mitochondria in medicine
    ​    Picard M, Wallace DC, Burelle Y. Mitochondrion 2016; 30:105-16   PubMed   PDF
    ​
  • The spectrum of mitochondrial ultrastructural defects in mitochondrial myopathy
    Vincent AE, Ng YS, White K, Davey T, Mannella C, Falkous G, Feeney C, Schaefer AM, McFarland R, Gorman GS, Taylor RW, 
    Turnbull DM, Picard M. Sci Rep 2016; 6:30610    PubMed   PDF   Suppl

  • Genetic evidence for elevated pathogenicity of mitochondrial DNA heteroplasmy in autism spectrum disorder
    Wang Y, Picard M, Gu Z. Plos Genet 2016; 12(10):e1006391    PubMed   PDF
    ​
  • Allostatic load and comorbidities: A mitochondrial, neuroepigenetic, and psychoevolutionary perspective
    Juster RP, Russell JJ, Almeidac D, Picard M. Dev Psychopathol 2016; 28(4pt1):1117:46   PubMed   PDF

  • Disentangling (epi)genetic and environmental contributions to the m.3243A>G MELAS mutation phenotype: Phenotypic destiny in mitochondrial disease?
    Picard M, Hirano M. JAMA Neurol 2016; 73(8):923-5   PubMed   PD

​2015
  • Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory and transcriptional responses to psychological stress
    Picard M, McManus MJ, Gray J, Nasca C, Moffat C, Kopinsky P, Seifert E, McEwen BS, Wallace DC. PNAS 2015; 112(48):E6614-23  PubMed       PDF

  • Mitochondrial synapses: Intracellular communication and signal integration
    Picard M.     Trends Neurosci 2015; 38(8):468-474   PubMed   PDF

  • Inter-mitochondrial coordination of cristae at regulated membrane junctions
    Picard M, McManus MJ, Csordas G, Varnai P, Dorn GW, Williams D, Hajnoczky G, Wallace DC. Nat Commun 2015; 6:6259  
    ​PubMed       PDF
    ​
  • Mitochondrial signaling in neurodegeneration 
    Picard M, McManus MJ. In Reeve AK, Simcox A, Duchen MR, Turnbull DM. (Eds.) Mitochondrial dysfunction in neurodegenerative disorders, 2nd edition, London: Springer (2016)   Link
    ​
2014
  • Mitochondrial allostatic load puts the ‘gluc’ back into glucocorticoids
    Picard M, Juster RP, McEwen BS.     Nat Rev Endocrinol 2014; 10(5):303-10   PubMed   PDF

  • Progressive increase in mtDNA 3243A>G heteroplasmy results in abrupt transcriptional remodeling
    Picard M, Zhang J, Hanecock S, Derbeneva O, Golhar R, Golik P, O’Hearn S, Levy SE, Potluri P, Lvova M, Davila A, Lin CS, Perin JC, Rappaport EF, Hakonarson H, Trounce I, Procaccio V, Wallace DC. PNAS 2014; 111(38):E4033;4042   PubMed       PDF

  • Mitochondria impact brain function and cognition
    Picard M and McEwen BS. PNAS 2014; 111(1):7-8 [Commentary]   PubMed   PDF
    ​
2013
  • Allostatic load as a tool for monitoring comorbidities in schizophrenia and bipolar disorder
    Bizik G, Picard M, Nijjer R, Tourjman V, McEwen BS, Lupien SJ, Juster RP. Harv Rev Neurosci 2013; 21(6):296-313   PubMed       PDF

  • Linking metabolic state and mitochondrial DNA in chronic disease, health and aging
    Picard M, Turnbull DM. Diabetes 2013; 62(3):672-8   PubMed       PDF

  • Mitochondrial morphology transitions and functions: Implications for retrograde signaling?
    Picard M, Shirihai O, Gentil BJ, Burelle Y. Am J Physiol Regul Integr Comp Physiol 2013; 304:R393-406   PubMed       PD

2012 and earlier
  • Mitochondria: Starving to reach quorum?
    Picard M and Burelle Y. Bioessays 2012; 43(4):272-4   PubMed       PDF

  • Pathways to aging: The mitochondrion at the intersection of biological and psychosocial sciences
    Picard M. J Aging Res 2011; 814096:1-11   PubMed       PDF

  • Mitochondria: Isolation, structure and function
    Picard M, Taivassalo T, Gouspillou G, Hepple RT. J Physiol (London) 2011; 589(18):4413-21   PubMed       PDF

  • A transdisciplinary perspective of chronic stress in relation to psychopathology throughout lifespan development
    Juster RP, Bizik G, Picard M, Arsenault-Lapierre G, Sindi S, Trepanier L, Marin MF, Wan N, Sekerovic Z, Lord C, Fiocco A, Plusquellec P, McEwen B, Lupien S. Dev Psychopathol 2011; 23(03):725-76    PubMed       PDF

  • Mitochondrial structure and function are disrupted by standard isolation methods
    Picard M, Taivassalo T, Ritchie D, Wright KJ, Thomas MM, Romestaing C, Hepple RT. PLoS One 2011; 6(3):e18317   PubMed        PDF

  • The need for a transdisciplinary, global health framework
    Picard M, Sabiston C, McNamara JK. J Alt Complement Med 2011; 17(2):179-84   PubMed       PDF​

Complete list of publications

Updated: October 2022