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PREPRINTS
2022
2020
2019
2018
2016
2015
2012 and earlier
Updated: December 2021
- Chronic glucocorticoid stress reveals increased energy expenditure and accelerated aging as cellular features of
allostatic load
Bobba-Alves N, Sturm G, Lin J, Ware SA, Karan KR, Monzel AS, Bris C, Procaccio V, Lenaers G, Higgins-Chen A, Levine M, Horvath S, Santhanam BS, Kaufman BA, Hirano M, Epel E, Picard M.
Preprint: www.biorxiv.org/content/10.1101/2022.02.22.481548v2 - Accelerating the clock: Interconnected speedup of energetic and molecular dynamics during aging in cultured human cells
Sturm G, Bobba-Alves N, Tumasian III RA, Michelson J, Ferrucci L, Kempes CP, Picard M.
Preprint: https://www.biorxiv.org/content/10.1101/2022.05.10.491392v1 - Mouse brain-wide mitochondrial connectivity anchored in gene, brain and behavior
Rosenberg A, Saggar M, Rogu P, Mosharov EV, Sandi C, Dumitriu D, Anacker C, Picard M.
Preprint: https://www.biorxiv.org/content/10.1101/2021.06.02.446767v2 - Dynamic behavior of cell-free mitochondrial DNA in human saliva
Trumpff C, Rausser S, Haahr R, Karan KR, Gouspillou G, Kirschbaum C, Picard M.
Preprint: https://www.biorxiv.org/content/10.1101/2021.09.15.460321v1 - A multi-omics and bioenergetics longitudinal aging dataset in primary human fibroblasts with mitochondrial perturbations
Sturm G, Monzel AS, Karan KR, Michelson J, Ware SA, Cardenas A, Lin J, Bris C, Santhanam B, Murphy MP, Levine ME, Horvath S,
Belsky D, Wang S, Procaccio V, Kaufman BA, Hirano M, Picard M.
Preprint: https://www.biorxiv.org/content/10.1101/2021.11.12.468448v3
- OxPhos dysfunction causes hypermetabolism and reduces lifespan in cells and in patients with mitochondrial diseases
Sturm G, Karan KR, Monzel AS, Santhanam BS, Taivassalo T, Bris C, Duplaga SA, Cross M, Towheed A, Higgins-Chen A, McManus MJ, Cardenas A, Lin J, Epel ES, Rahman S, Vissing V, Grassi B, Levine M, Horvath S, Haller RG, Lanaers G, Wallace DC, Tavazoie S, Procaccio V, Kaufman BA, Seifert EL, Hirano H, Picard M.
Preprint: https://www.biorxiv.org/content/10.1101/2021.11.29.470428v2
2022
- Integrating sex and gender in mitochondrial science
Junker A, Juster RP, Picard M. Curr Opin Physiol 2022 (in press) Link PDF - Leukocyte cytokine responses in adult patients with mitochondrial DNA defects
Karan KR, Trumpff C, Cross M, Englestad KM, Marsland AL, McGuire P, Hirano M, Picard M. J Mol Med (in press) Preprint
- Mitochondrial respiratory chain protein co-regulation in the human brain
Trumpff C, Owusu-Ansah E, Klein H, Lee A, Petyuk V, Wingo TS, Wingo AP, Thambisetty M, Ferrucci L, Seyfried NT, Bennett DA, De Jager PL, Picard M. Heliyon (in press) Link PDF - Why do we care more about disease than health
Picard M. Phenomics 2022; PubMed PDF - Human studies of mitochondrial biology demonstrate an overall lack of binary sex differences: A multivariate meta-analysis
Junker A, Wang J, Gouspillou G, Ehinger JK, Elmér E, Sjövall F, Fisher-Wellman K, Neufer PD, Molina AJA, Ferrucci L, Picard M.
FASEB J 2022; 36:e22146 PubMed PDF
- Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures
Rausser S, Trumpff C, McGill MA, Junker A, Wang W, Ho S, Mitchell A, Karan K, Monk C, Segerstrom S, Reed R, Picard M.
eLife 2021; 10:e70899 PubMed PDF - Mitochondrial DNA quantity and quality in the human aged and Alzheimer’s disease brain.
Klein H, Trumpff C, Yang HS, Lee AJ, Picard M, Bennett DA, De Jager. Mol Neurodegener 2021;16:75 PubMed PDF - Quantitative mapping of human hair graying and reversal in relation to life stress
Rosenberg A, Rausser S, Ren J, Mosharov EV, Sturm G, Ogden RT, Patel P, Soni RK, Lacefield C, Tobin DJ, Paus R, Picard M.
eLife 2021; 10:e67437 PubMed PDF eLife Digest - 3D neuronal mitochondrial morphology in axons, dendrites, and cell bodies of the aging mouse hippocampus.
Faitg J, Lacefied C, Davey T, White K, Laws R, Kosmidi S, Reeve AK, Kandel E, Vincent AE, Picard M. Cell Rep 2021; 36(6): 109509 PubMed PDF - Stress and circulating cell-free mitochondrial DNA: a systematic review of human studies, physiological considerations, and technical recommendations.
Trumpff C, Michelson J, Lagranha CJ, Taleon V, Karan K, Sturm G, Lindqvist D, Fernström J, Moser D, Kaufman BA, Picard M.
Mitochondrion 59:225-245 PubMed PDF Protocol - Mitochondria in epithelial ovarian carcinoma exhibit abnormal phenotypes and blunted associations with biobehavioral factors
Bindra S, McGill MA, Triplett MK, Tyagi A, Thaker PH, Dahmoush L, Goodheart MJ, Ogden RT, E Owusu-Ansah, Karan KR, Cole S, Sood AK, Lutgendorf SK, Picard M. Sci Rep 2021; 11:11595 PubMed PDF - Blood mtDNA copy number: What are we counting?
Picard M. Mitochondrion 2021 (in press) PubMed PDF - The social nature of mitochondria: Implications for human health
Picard M, Sandi C. Neurosci Biobehav Rev 2021; 120(5):595-610 PubMed PDF
2020
- Mitochondrial respiratory chain function modulates LPS-induced inflammatory signatures in human blood
Karan KR, Trumpff C, McGill MA, Thomas JE, Sturm G, Lauriola V, Sloan RP, Rohleder N, Kaufman BK, Marsland AL, Picard M.
Brain Behav Immun-Health 2020; 100080 PubMed PDF Suppl
2019
- Mitochondrial psychobiology: Foundation and applications
Picard M, Trumpff C, Burelle Y. Curr Opin Behav Sci 2020; PDF
- Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts
Sturm G, Cardenas A, Bind MA, Horvath S, Wang S, Wang Y, Hägg S, Hirano M, Picard M. Epigenetics 201914(10):961-976 PubMed PDF - Predictors of ccf-mtDNA reactivity to acute psychological stress identified using machine learning classifiers: A proof-of-concept
Trumpff C, Marsland AL, Sloan RP, Kaufman BK, Picard M. Psychoneuroendocrinol 2019; 107:82-92 PubMed PDF - Acute psychological stress increases serum circulating cell-free mitochondrial DNA
Trumpff C, Marsland AL, Basualto C, Martin JL, Carroll JE, Sturm G, Gu Z, Vincent A, Kaufman BA, Picard M. Psychoneuroendocrinol 2019; 106:268-276 PubMed PDF
- Accelerating research on biological aging and mental health: Current challenges and future directions
Han LKM, Verhoeven JE, Tyrka A, Penninx BWJH, Wolkowitz OM, Månsson KNT, Lindqvist D, Vinkers CH, Boks MP, Révész D, Mellon SH, Picard M. Psychoneuroendocrinol 2019; 106:293-311 PubMed PDF
- Quantitative 3D mapping of the human skeletal muscle mitochondrial network
Vincent AE, White K, Davey T, Philips J, Ogden RT, Lawess C, Warren C, Hall MG, Ng YS, Falkous G, Holden T, Deehan D, Taylor RW, Turnbull DM, Picard M. Cell Rep 2019; 26(4):996-1009 PubMed PDF
2018
- Sub-cellular origin of mtDNA deletions in human skeletal muscle
Vincent AE, Rosa HS, Pabis K, Lawless C, Grünewald A, Chen C, Rygiel KA, Rocha MC, Falkous G, Perissi V, White K, Davey T, Grady JP, Petrof B, Sayer AA, Cooper C, Taylor RW, Turnbull DM, Picard M. Annals Neurol 2018; 84(2):289-301 PubMed PDF - Mitochondrial dynamics in adaptive and maladaptive cellular stress responses
Eisner V, Picard M, Hajnoczky G. Nat Cell Biol 2018; 20(7):655-665 PubMed PDF - A mitochondrial health index sensitive to mood and caregiver stress
Picard M, Prather AA, Puterman E, Cuillerier A, Coccia M, Aschbacher K, Burelle Y, Epel ES. Biol Psychiatr 2018; 84(1):9-17 PubMed PDF - Psychological stress and mitochondria: A systematic review (Part I)
Picard M, McEwen BS. Psychosom Med 2018; 80(2):141-153 PubMed PDF
- Psychological stress and mitochondria: A conceptual framework (Part II)
Picard M, McEwen BS. Psychosom Med 2018; 80(2):126-140 PubMed PDF - An energetic view of stress: Focus on mitochondria
Picard M, McEwen BS, Epel ES, Sandi C. Front Neuroendocrinol2018; 49:72-85 PubMed PDF
- Mitochondrial nanotunnels
Vincent AE, Turnbull DM, Hajnoczky G, Eisner V, Picard M. Trends Cell Biol 2017; 27(11):787-799 PubMed PDF Suppl - Independent impacts of aging on mitochondrial DNA quantity and quality in humans
Zhang R, Wang Y, Ye K, Picard M, Gu Z. BMC Genomics 2017; 18:890 PubMed - Mitochondrial nexus to allostatic load biomarkers
Picard M, Juster RP, Sloan RP, McEwen BS. Psychosom Med 2017; 79(1):114-117 PubMed PD
2016
- The rise of mitochondria in medicine
Picard M, Wallace DC, Burelle Y. Mitochondrion 2016; 30:105-16 PubMed PDF
- The spectrum of mitochondrial ultrastructural defects in mitochondrial myopathy
Vincent AE, Ng YS, White K, Davey T, Mannella C, Falkous G, Feeney C, Schaefer AM, McFarland R, Gorman GS, Taylor RW,
Turnbull DM, Picard M. Sci Rep 2016; 6:30610 PubMed PDF Suppl - Genetic evidence for elevated pathogenicity of mitochondrial DNA heteroplasmy in autism spectrum disorder
Wang Y, Picard M, Gu Z. Plos Genet 2016; 12(10):e1006391 PubMed PDF
- Allostatic load and comorbidities: A mitochondrial, neuroepigenetic, and psychoevolutionary perspective
Juster RP, Russell JJ, Almeidac D, Picard M. Dev Psychopathol 2016; 28(4pt1):1117:46 PubMed PDF - Disentangling (epi)genetic and environmental contributions to the m.3243A>G MELAS mutation phenotype: Phenotypic destiny in mitochondrial disease?
Picard M, Hirano M. JAMA Neurol 2016; 73(8):923-5 PubMed PD
2015
- Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory and transcriptional responses to psychological stress
Picard M, McManus MJ, Gray J, Nasca C, Moffat C, Kopinsky P, Seifert E, McEwen BS, Wallace DC. PNAS 2015; 112(48):E6614-23 PubMed PDF - Mitochondrial synapses: Intracellular communication and signal integration
Picard M. Trends Neurosci 2015; 38(8):468-474 PubMed PDF - Inter-mitochondrial coordination of cristae at regulated membrane junctions
Picard M, McManus MJ, Csordas G, Varnai P, Dorn GW, Williams D, Hajnoczky G, Wallace DC. Nat Commun 2015; 6:6259
PubMed PDF
- Mitochondrial signaling in neurodegeneration
Picard M, McManus MJ. In Reeve AK, Simcox A, Duchen MR, Turnbull DM. (Eds.) Mitochondrial dysfunction in neurodegenerative disorders, 2nd edition, London: Springer (2016) Link
- Mitochondrial allostatic load puts the ‘gluc’ back into glucocorticoids
Picard M, Juster RP, McEwen BS. Nat Rev Endocrinol 2014; 10(5):303-10 PubMed PDF - Progressive increase in mtDNA 3243A>G heteroplasmy results in abrupt transcriptional remodeling
Picard M, Zhang J, Hanecock S, Derbeneva O, Golhar R, Golik P, O’Hearn S, Levy SE, Potluri P, Lvova M, Davila A, Lin CS, Perin JC, Rappaport EF, Hakonarson H, Trounce I, Procaccio V, Wallace DC. PNAS 2014; 111(38):E4033;4042 PubMed PDF - Mitochondria impact brain function and cognition
Picard M and McEwen BS. PNAS 2014; 111(1):7-8 [Commentary] PubMed PDF
- Allostatic load as a tool for monitoring comorbidities in schizophrenia and bipolar disorder
Bizik G, Picard M, Nijjer R, Tourjman V, McEwen BS, Lupien SJ, Juster RP. Harv Rev Neurosci 2013; 21(6):296-313 PubMed PDF - Linking metabolic state and mitochondrial DNA in chronic disease, health and aging
Picard M, Turnbull DM. Diabetes 2013; 62(3):672-8 PubMed PDF - Mitochondrial morphology transitions and functions: Implications for retrograde signaling?
Picard M, Shirihai O, Gentil BJ, Burelle Y. Am J Physiol Regul Integr Comp Physiol 2013; 304:R393-406 PubMed PD
2012 and earlier
- Mitochondria: Starving to reach quorum?
Picard M and Burelle Y. Bioessays 2012; 43(4):272-4 PubMed PDF - Pathways to aging: The mitochondrion at the intersection of biological and psychosocial sciences
Picard M. J Aging Res 2011; 814096:1-11 PubMed PDF - Mitochondria: Isolation, structure and function
Picard M, Taivassalo T, Gouspillou G, Hepple RT. J Physiol (London) 2011; 589(18):4413-21 PubMed PDF - A transdisciplinary perspective of chronic stress in relation to psychopathology throughout lifespan development
Juster RP, Bizik G, Picard M, Arsenault-Lapierre G, Sindi S, Trepanier L, Marin MF, Wan N, Sekerovic Z, Lord C, Fiocco A, Plusquellec P, McEwen B, Lupien S. Dev Psychopathol 2011; 23(03):725-76 PubMed PDF - Mitochondrial structure and function are disrupted by standard isolation methods
Picard M, Taivassalo T, Ritchie D, Wright KJ, Thomas MM, Romestaing C, Hepple RT. PLoS One 2011; 6(3):e18317 PubMed PDF - The need for a transdisciplinary, global health framework
Picard M, Sabiston C, McNamara JK. J Alt Complement Med 2011; 17(2):179-84 PubMed PDF
Updated: December 2021