Using high-resolution quantitative imaging approaches and omics technologies, we study how mitochondria interact with
each other and with the cell nucleus
where they regulate gene expression
and cellular aging.
Inherited mitochondrial diseases are a group of clinically heterogenous disorders that cause disability and mortality. There is currently no cure, so we work to better understand the disease process. We are currently running the MiSBIE study.
The experience of chronic psychological and social stress accelerates cellular aging and predisposes to age-related diseases. We examine the role of mitochondria
in mind-body interactions and in
the stress-disease cascade.
"Clearly, an understanding of the simple is necessary to understand the more complex, but whether it is sufficient is questionable."
- François Jacob, Science (1977)