PREPRINTS
2024
2023
2019 and earlier
- Blood mitochondrial health markers cf-mtDNA and GDF15 in human aging
Trumpff C, Huang Q, Liu CC, Habeck C, Stern Y, Belsky DW, Picard M.
Preprint: https://www.biorxiv.org/content/10.1101/2025.01.28.635306v1 - Accelerating the clock: Interconnected speedup of energetic and molecular dynamics during aging in cultured human cells
Sturm G, Bobba-Alves N, Tumasian III RA, Michelson J, Ferrucci L, Kempes CP, Picard M.
Preprint: https://www.biorxiv.org/content/10.1101/2022.05.10.491392v4
2024
- The brain-body energy conservation model of aging
Shaulson ED, Cohen AA, Picard M. Nat Aging 2024 Link PDF Peer Review
- Neurodegenerative disorders, metabolic icebergs, and mitohormesis
Phillips, MCL, Picard, M. Transl Neurodegener 2024 Link PDF
2023
- Cellular allostatic load is linked to increased energy expenditure and accelerated biological aging
Bobba-Alves N, Sturm G, Lin J, Ware SA, Karan KR, Monzel AS, Bris C, Procaccio V, Lenaers G, Higgins-Chen A, Levine M, Horvath S, Santhanam BS, Kaufman BA, Hirano M, Epel E, Picard M. Psychoneuroendocrinology 2023 Link PDF - OxPhos defects cause hypermetabolism and reduce lifespan in cells and patients with mitochondrial diseases
Sturm G, Karan KR, Monzel AS, Santhanam BS, Taivassalo T, Bris C, Duplaga SA, Cross M, Towheed A, Higgins-Chen A, McManus MJ, Cardenas A, Lin J, Epel ES, Rahman S, Vissing V, Grassi B, Levine M, Horvath S, Haller RG, Lanaers G, Wallace DC, Tavazoie S, Procaccio V, Kaufman BA, Seifert EL, Hirano H, Picard M. Commun Biol 2023 Link PDF
- A multi-omic and bioenergetics longitudinal aging dataset in primary human fibroblasts with mitochondrial perturbations
Sturm G, Monzel AS, Karan KR, Michelson J, Ware SA, Cardenas A, Lin J, Bris C, Santhanam B, Murphy MP, Levine ME, Horvath S,
Belsky D, Wang S, Procaccio V, Kaufman BA, Hirano M, Picard M. Sci Data 2022 Link PDF
- The energetic cost of allostatic load
Bobba-Alves N, Juster RP, Picard M. Psychoneuroendocrinology 2022 Link PDF
- Quantitative mapping of human hair graying and reversal in relation to life stress
Rosenberg A, Rausser S, Ren J, Mosharov EV, Sturm G, Ogden RT, Patel P, Soni RK, Lacefield C, Tobin DJ, Paus R, Picard M.
eLife 2021 PubMed PDF eLife Digest
2019 and earlier
- Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts
Sturm G, Cardenas A, Bind MA, Horvath S, Wang S, Wang Y, Hägg S, Hirano M, Picard M. Epigenetics 2019 PubMed PDF
- Independent impacts of aging on mitochondrial DNA quantity and quality in humans
Zhang R, Wang Y, Ye K, Picard M, Gu Z. BMC Genomics 2017 PubMed
