PREPRINTS
2025
2024
2020
2019
2018
2016
2015
2012 and earlier
Updated: April 2024
- The Energy Resistance Principle
Picard M, Murugan NJ.
Preprint: https://osf.io/preprints/osf/hgnmj_v2 - Blood mitochondrial health markers cf-mtDNA and GDF15 in human aging
Trumpff C, Huang Q, Liu CC, Habeck C, Stern Y, Belsky DW, Picard M.
Preprint: https://www.biorxiv.org/content/10.1101/2025.01.28.635306v1 - Mitochondrial and Stress-Related Psychobiological Regulation of FGF21 in Humans
Kurade M, Bobba-Alves N, Kelly C, Behnke A, Conklin Q, Juster RP, Hirano M, Trumpff C, Picard M.
Preprint: https://www.medrxiv.org/content/10.1101/2025.01.30.25321437v1 - Immune mitochondrial pehonotypes are largely preserved in mitochondrial diseases and do not reflect disease severity
Liu CC, Kurade M, Monzel AS, Kelly C, Juster RP, Trumpff C, Hirano M, Picard M.
Preprint: https://www.biorxiv.org/content/10.1101/2025.01.18.633635v2 - A Quantitative approach to mapping mitochondrial specialization and plasticity
Monzel AS, Devine J, Kapri D, Enriquez JA, Trumpff C, Picard M.
Preprint: https://www.biorxiv.org/content/10.1101/2025.02.03.635951v3
- The energetic stress marker GDF15 is induced by acute psychosocial stress
Huang Q, Monzel AS, Rausser S, Haahr R, Devine J, Liu CC, Kelly C, Thompson E, Kurade M, Michelson J, Shaulson ED, Li S, Engelstad K, Tanji K, Lauriola V, Wang T, Wang S, Zuraikat FM, St-Onge MP, Kaufman BA, Sloan R, Juster RP, Marsland AL, Gouspillou G, Hirano M, Picard M, Trumpff C.
Preprint: www.biorxiv.org/content/10.1101/2024.04.19.590241v5
- Accelerated physiology and increased energy expenditure in animals and humans with mitochondrial defects: A meta-analysis
Sercel A, Sturm G, Shaulson ED, Gallagher D, St-Onge MP, Kempes C, Pontzer H, Hirano M, Picard M.
Preprint: https://www.biorxiv.org/content/10.1101/2023.09.09.556754v1 - Accelerating the clock: Interconnected speedup of energetic and molecular dynamics during aging in cultured human cells
Sturm G, Bobba-Alves N, Tumasian III RA, Michelson J, Ferrucci L, Kempes CP, Picard M.
Preprint: https://www.biorxiv.org/content/10.1101/2022.05.10.491392v4
2025
- Brain and body energy metabolism and potential for treatment of psychiatric disorders
Andreazza A, Barros F, Behnke A, Ben-Shachar D, Berretta S, Chouinard VA, Do K, Thanarajah SE, Ehrenreich H, Falkai P, Ford J, Freyberg Z, Gilbert-Jaramillo J, Glausier J, Goyal MS, Hahn M, Herculano-Houzel S, Hofmann D, Tatjana Kolassa I, Mack M, Mavioglu RN, McCullumsmith R, Milaneschi Y, Molina A, Mujica-Parodi L, Öngür D, Paulus M, Peleg-Raibstein D, Perry B, Picard M, Pillinger T, Rae C, Rothman D, Sarnyai Z, Steiner J, Upthegrove R, Vernon A, Wall M, Weistuch C. Nat Mental Health 2025 Link PDF - The mitochondrial disease biomarker GDF15 is quantifiable in saliva, exhibits dynamic properties and correlates with disease severity
Huang Q, Trumpff C, Monzel AS, Rausser S, Devine J, Liu CC, Kelly C, Kurade M, Li S, Engelstad K, Tani K, Lauriola V, Wang T, Wang S, Sloan R, Juster RP, Hirano M, Picard M. Mol Genet Metab 2025 Link PDF - Perceived association of mood and symptom severity in adults with mitochondrial diseases
Kelly C, Cross M, Junker A, Engelstad K, Rosales X, Hirano M, Trumpff C, Picard M. Mitochondrion 2025 Link PDF - Saliva and blood cell-free mtDNA reactivity to acute psychosocial stress
Trumpff C, Shire D, Michelson J, Bobba-Alves N, Yu T, Sloan RP, Juster RP, Hirano M, Picard M. Psychoneuroendocrinology 2025 Link PDF - Intrinsic health as a foundation for a science of health
Cohen AA, Picard M, Beard JR, Belsky DW, Herbstman J, Kuryla CL, Liu M, Makarem N, Malinsky D, Pei S, Wei Y, Fried LP. Science Advances 2025 Link PDF - Brain-body mitochondrial distribution patterns lack coherence and point to tissue-specific regulatory mechanisms
Devine J, Monzel AS, Shire D, Rosenberg AM, Junker A, Cohen AA, Picard M. Life Metab 2025 Link PDF - Mitochondria - the CEO of the cell
Lee-Glover LP, Picard M, Shutt, TE. J Cell Sci 2025 Link PDF - A human brain map of mitochondrial respiratory capacity and diversity
Mosharov EV, Rosenberg AM, Monzel AS, Osto CA, Stiles L, Rosoklija GB, Dwork AJ, Bindra S, Junker A, Zhang Y, Fujita M, Mariani MB, Bakalian M, Sulzer D, De Jager PL, Menon V, Shirihai OS, Mann JJ, Underwood M, Boldrini M, Thiebaut de Schotten M, Picard M. Nature 2025 Link PDF Briefing
2024
- A platform to map the mind-mitochondria connection and the hallmarks of psychobiology: The MiSBIE Study
Kelly C, Trumpff C, Acosta C, Assuras S, Baker J, Basarrate S, Behnke A, Bo K, Bobba-Alves N, Champagne FA, Conklin Q, Cross M, De Jager P, Engelstad K, Epel A, Franklin SG, Hirano M, Huang Q, Junker A, Juster RP, Kapri D, Kirschbaum C, Kurade M, Lauriola V, Li S, Liu CC, Liu G, McEwen BS, McGill MA, McIntyre K, Monzel AS, Michelson J, Prather AA, Puterman E, Rosales X, Shapiro PA, Shire D, SlavichGM, Sloan RP, Smith JLM, Spann M, Spicer J, Sturm G, Tepler S, Thiebaut de Schotten M, Wager TD, Picard M, The MiSBIE Study Group. Trends Endocrinol Metab 2024 Link PDF - The brain-body energy conservation model of aging
Shaulson ED, Cohen AA, Picard M. Nat Aging 2024 Link PDF Peer Review - Neurodegenerative disorders, metabolic icebergs, and mitohormesis
Phillips, MCL, Picard, M. Transl Neurodegener 2024 Link PDF - Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate in aging fibroblasts
Zhou W, Karan KR, Klein H, Sturm G, De Jager P, Bennett D, Hirano M, Picard M, Mills R. PLoS Biol 2024 Link PDF - Psychosocial experiences are associated with human brain mitochondrial biology
Trumpff, C, Monzel A, Sandi C, Menon V, Klein H-U, Fujita M, Lee A, Petyuk VA, Hurst C, Duong DM, Seyfried NT, Wingo AP, Wingo TS, Wang Y, Thambisetty M, Ferrucci L, Bennett DA, De Jager PL, Picard M. PNAS 2024 Link PDF - Hypermetabolism and energetic constraints in mitochondrial disorders
Sercel A, Sturm G, Kempes C, Gallagher D, St-Onge MP, Pontzer H, Hirano M, Picard M. Nat Metab 2024 Link PDF - Distribution of glucocorticoid and adrenergic receptors across human organs and tissues: a map for stress transduction.
Basarrate S, Monzel AS, Smith J, Marsland A, Trumpff C, Picard M. Psychosom Med 2024 Link PDF
- The energetics of cellular life transitions
Monzel AS, Levin M, Picard M. Life Metab 2023 Link PDF - Mitochondrial diversity and network organization predict anxiety-like behavior in mice.
Rosenberg A, Saggar M, Monzel AS, Devine J, Rogu P, Mosharov EV, Junker A, Sandi C, Dumitriu D, Anacker C, Picard M. Nat Commun 2023 Link PDF - MitoQuicLy: A high-throughput method for quantifying cell-free DNA from human plasma, serum, and saliva
Michelson J, Rausser S, Peng A, Yu T, Sturm G, Trumpff C, Kaufman BA, Rai AJ, Picard M. Mitochondrion 2023 Link PDF - Cellular allostatic load is linked to increased energy expenditure and accelerated biological aging
Bobba-Alves N, Sturm G, Lin J, Ware SA, Karan KR, Monzel AS, Bris C, Procaccio V, Lenaers G, Higgins-Chen A, Levine M, Horvath S, Santhanam BS, Kaufman BA, Hirano M, Epel E, Picard M. Psychoneuroendocrinology 2023 Link PDF - Multifaceted mitochondria: Moving mitochondrial science beyond function and dysfunction
Monzel AS, Enriques JA, Picard M. Nat Metab 2023 Link PDF - OxPhos defects cause hypermetabolism and reduce lifespan in cells and patients with mitochondrial diseases
Sturm G, Karan KR, Monzel AS, Santhanam BS, Taivassalo T, Bris C, Duplaga SA, Cross M, Towheed A, Higgins-Chen A, McManus MJ, Cardenas A, Lin J, Epel ES, Rahman S, Vissing V, Grassi B, Levine M, Horvath S, Haller RG, Lanaers G, Wallace DC, Tavazoie S, Procaccio V, Kaufman BA, Seifert EL, Hirano H, Picard M. Commun Biol 2023 Link PDF
- Mitochondrial signal transduction
Picard M, Shirihai OS. Cell Metabolism 2022 Link PDF - A multi-omic and bioenergetics longitudinal aging dataset in primary human fibroblasts with mitochondrial perturbations
Sturm G, Monzel AS, Karan KR, Michelson J, Ware SA, Cardenas A, Lin J, Bris C, Santhanam B, Murphy MP, Levine ME, Horvath S,
Belsky D, Wang S, Procaccio V, Kaufman BA, Hirano M, Picard M. Sci Data 2022 Link PDF
- The energetic cost of allostatic load
Bobba-Alves N, Juster RP, Picard M. Psychoneuroendocrinology 2022 Link PDF - Dynamic behavior of cell-free mitochondrial DNA in human saliva
Trumpff C, Rausser S, Haahr R, Karan KR, Gouspillou G, Putterman E, Kirschbaum C, Picard M. Psychoneuroendocrinology 2022 Link PDF - Mitochondrial respiratory chain protein co-regulation in the human brain
Trumpff C, Owusu-Ansah E, Klein H, Lee A, Petyuk V, Wingo TS, Wingo AP, Thambisetty M, Ferrucci L, Seyfried NT, Bennett DA, De Jager PL, Picard M. Heliyon 2022 Link PDF - Leukocyte cytokine responses in adult patients with mitochondrial DNA defects
Karan KR, Trumpff C, Cross M, Englestad KM, Marsland AL, McGuire P, Hirano M, Picard M. J Mol Med 2022 Link PDF - Why do we care more about disease than health?
Picard M. Phenomics 2022 Link PDF - Human studies of mitochondrial biology demonstrate an overall lack of binary sex differences: A multivariate meta-analysis
Junker A, Wang J, Gouspillou G, Ehinger JK, Elmér E, Sjövall F, Fisher-Wellman K, Neufer PD, Molina AJA, Ferrucci L, Picard M.
FASEB J 2022 Link PDF - Integrating sex and gender in mitochondrial science
Junker A, Juster RP, Picard M. Curr Opin Physiol 2022 Link PDF - Energy transduction and the mind-mitochondria connection
Picard M. The Biochemist 2022 Link PDF
- Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures
Rausser S, Trumpff C, McGill MA, Junker A, Wang W, Ho S, Mitchell A, Karan K, Monk C, Segerstrom S, Reed R, Picard M.
eLife 2021 PubMed PDF - Mitochondrial DNA quantity and quality in the human aged and Alzheimer’s disease brain.
Klein H, Trumpff C, Yang HS, Lee AJ, Picard M, Bennett DA, De Jager. Mol Neurodegener 2021 PubMed PDF - Quantitative mapping of human hair graying and reversal in relation to life stress
Rosenberg A, Rausser S, Ren J, Mosharov EV, Sturm G, Ogden RT, Patel P, Soni RK, Lacefield C, Tobin DJ, Paus R, Picard M.
eLife 2021 PubMed PDF eLife Digest - 3D neuronal mitochondrial morphology in axons, dendrites, and cell bodies of the aging mouse hippocampus.
Faitg J, Lacefied C, Davey T, White K, Laws R, Kosmidi S, Reeve AK, Kandel E, Vincent AE, Picard M. Cell Rep 2021 PubMed PDF - Stress and circulating cell-free mitochondrial DNA: a systematic review of human studies, physiological considerations, and technical recommendations.
Trumpff C, Michelson J, Lagranha CJ, Taleon V, Karan K, Sturm G, Lindqvist D, Fernström J, Moser D, Kaufman BA, Picard M.
Mitochondrion 2021 PubMed PDF Protocol - Mitochondria in epithelial ovarian carcinoma exhibit abnormal phenotypes and blunted associations with biobehavioral factors
Bindra S, McGill MA, Triplett MK, Tyagi A, Thaker PH, Dahmoush L, Goodheart MJ, Ogden RT, E Owusu-Ansah, Karan KR, Cole S, Sood AK, Lutgendorf SK, Picard M. Sci Rep 2021 PubMed PDF - Blood mtDNA copy number: What are we counting?
Picard M. Mitochondrion 2021 Link PDF - The social nature of mitochondria: Implications for human health
Picard M, Sandi C. Neurosci Biobehav Rev 2021 PubMed PDF
2020
- Mitochondrial respiratory chain function modulates LPS-induced inflammatory signatures in human blood
Karan KR, Trumpff C, McGill MA, Thomas JE, Sturm G, Lauriola V, Sloan RP, Rohleder N, Kaufman BK, Marsland AL, Picard M.
Brain Behav Immun-Health 2020 PubMed PDF Suppl
2019
- Mitochondrial psychobiology: Foundation and applications
Picard M, Trumpff C, Burelle Y. Curr Opin Behav Sci 2019 Link PDF
- Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts
Sturm G, Cardenas A, Bind MA, Horvath S, Wang S, Wang Y, Hägg S, Hirano M, Picard M. Epigenetics 2019 PubMed PDF - Predictors of ccf-mtDNA reactivity to acute psychological stress identified using machine learning classifiers: A proof-of-concept
Trumpff C, Marsland AL, Sloan RP, Kaufman BK, Picard M. Psychoneuroendocrinol 2019 PubMed PDF - Acute psychological stress increases serum circulating cell-free mitochondrial DNA
Trumpff C, Marsland AL, Basualto C, Martin JL, Carroll JE, Sturm G, Gu Z, Vincent A, Kaufman BA, Picard M. Psychoneuroendocrinol 2019 PubMed PDF
- Accelerating research on biological aging and mental health: Current challenges and future directions
Han LKM, Verhoeven JE, Tyrka A, Penninx BWJH, Wolkowitz OM, Månsson KNT, Lindqvist D, Vinkers CH, Boks MP, Révész D, Mellon SH, Picard M. Psychoneuroendocrinol 2019 PubMed PDF
- Quantitative 3D mapping of the human skeletal muscle mitochondrial network
Vincent AE, White K, Davey T, Philips J, Ogden RT, Lawess C, Warren C, Hall MG, Ng YS, Falkous G, Holden T, Deehan D, Taylor RW, Turnbull DM, Picard M. Cell Rep 2019 PubMed PDF
2018
- Sub-cellular origin of mtDNA deletions in human skeletal muscle
Vincent AE, Rosa HS, Pabis K, Lawless C, Grünewald A, Chen C, Rygiel KA, Rocha MC, Falkous G, Perissi V, White K, Davey T, Grady JP, Petrof B, Sayer AA, Cooper C, Taylor RW, Turnbull DM, Picard M. Annals Neurol 2018 PubMed PDF
- Mitochondrial dynamics in adaptive and maladaptive cellular stress responses
Eisner V, Picard M, Hajnoczky G. Nat Cell Biol 2018 PubMed PDF - A mitochondrial health index sensitive to mood and caregiver stress
Picard M, Prather AA, Puterman E, Cuillerier A, Coccia M, Aschbacher K, Burelle Y, Epel ES. Biol Psychiatr 2018 PubMed PDF - Psychological stress and mitochondria: A systematic review (Part I)
Picard M, McEwen BS. Psychosom Med 2018 PubMed PDF
- Psychological stress and mitochondria: A conceptual framework (Part II)
Picard M, McEwen BS. Psychosom Med 2018 PubMed PDF - An energetic view of stress: Focus on mitochondria
Picard M, McEwen BS, Epel ES, Sandi C. Front Neuroendocrinol2018 PubMed PDF
- Mitochondrial nanotunnels
Vincent AE, Turnbull DM, Hajnoczky G, Eisner V, Picard M. Trends Cell Biol 2017 PubMed PDF Suppl - Independent impacts of aging on mitochondrial DNA quantity and quality in humans
Zhang R, Wang Y, Ye K, Picard M, Gu Z. BMC Genomics 2017 PubMed - Mitochondrial nexus to allostatic load biomarkers
Picard M, Juster RP, Sloan RP, McEwen BS. Psychosom Med 2017 PubMed PDF
2016
- The rise of mitochondria in medicine
Picard M, Wallace DC, Burelle Y. Mitochondrion 2016 PubMed PDF
- The spectrum of mitochondrial ultrastructural defects in mitochondrial myopathy
Vincent AE, Ng YS, White K, Davey T, Mannella C, Falkous G, Feeney C, Schaefer AM, McFarland R, Gorman GS, Taylor RW,
Turnbull DM, Picard M. Sci Rep 2016 PubMed PDF Suppl - Genetic evidence for elevated pathogenicity of mitochondrial DNA heteroplasmy in autism spectrum disorder
Wang Y, Picard M, Gu Z. Plos Genet 2016 PubMed PDF
- Allostatic load and comorbidities: A mitochondrial, neuroepigenetic, and psychoevolutionary perspective
Juster RP, Russell JJ, Almeidac D, Picard M. Dev Psychopathol 2016 PubMed PDF - Disentangling (epi)genetic and environmental contributions to the m.3243A>G MELAS mutation phenotype: Phenotypic destiny in mitochondrial disease?
Picard M, Hirano M. JAMA Neurol 2016 PubMed PDF
2015
- Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory and transcriptional responses to psychological stress
Picard M, McManus MJ, Gray J, Nasca C, Moffat C, Kopinsky P, Seifert E, McEwen BS, Wallace DC. PNAS 2015 PubMed PDF - Mitochondrial synapses: Intracellular communication and signal integration
Picard M. Trends Neurosci 2015 PubMed PDF - Inter-mitochondrial coordination of cristae at regulated membrane junctions
Picard M, McManus MJ, Csordas G, Varnai P, Dorn GW, Williams D, Hajnoczky G, Wallace DC. Nat Commun 2015 PubMed PDF
- Mitochondrial signaling in neurodegeneration
Picard M, McManus MJ. In Reeve AK, Simcox A, Duchen MR, Turnbull DM. (Eds.) Mitochondrial dysfunction in neurodegenerative disorders, 2nd edition, London: Springer (2016) Link
- Mitochondrial allostatic load puts the ‘gluc’ back into glucocorticoids
Picard M, Juster RP, McEwen BS. Nat Rev Endocrinol 2014 PubMed PDF - Progressive increase in mtDNA 3243A>G heteroplasmy results in abrupt transcriptional remodeling
Picard M, Zhang J, Hanecock S, Derbeneva O, Golhar R, Golik P, O’Hearn S, Levy SE, Potluri P, Lvova M, Davila A, Lin CS, Perin JC, Rappaport EF, Hakonarson H, Trounce I, Procaccio V, Wallace DC. PNAS 2014 PubMed PDF - Mitochondria impact brain function and cognition
Picard M and McEwen BS. PNAS 2014 [Commentary] PubMed PDF
- Allostatic load as a tool for monitoring comorbidities in schizophrenia and bipolar disorder
Bizik G, Picard M, Nijjer R, Tourjman V, McEwen BS, Lupien SJ, Juster RP. Harv Rev Neurosci 2013 PubMed PDF - Linking metabolic state and mitochondrial DNA in chronic disease, health and aging
Picard M, Turnbull DM. Diabetes 2013 PubMed PDF - Mitochondrial morphology transitions and functions: Implications for retrograde signaling?
Picard M, Shirihai O, Gentil BJ, Burelle Y. Am J Physiol Regul Integr Comp Physiol 2013 PubMed PDF
2012 and earlier
- Mitochondria: Starving to reach quorum?
Picard M and Burelle Y. Bioessays 2012 PubMed PDF - Pathways to aging: The mitochondrion at the intersection of biological and psychosocial sciences
Picard M. J Aging Res 2011 PubMed PDF - Mitochondria: Isolation, structure and function
Picard M, Taivassalo T, Gouspillou G, Hepple RT. J Physiol (London) 2011 PubMed PDF - A transdisciplinary perspective of chronic stress in relation to psychopathology throughout lifespan development
Juster RP, Bizik G, Picard M, Arsenault-Lapierre G, Sindi S, Trepanier L, Marin MF, Wan N, Sekerovic Z, Lord C, Fiocco A, Plusquellec P, McEwen B, Lupien S. Dev Psychopathol 2011 PubMed PDF - Mitochondrial structure and function are disrupted by standard isolation methods
Picard M, Taivassalo T, Ritchie D, Wright KJ, Thomas MM, Romestaing C, Hepple RT. PLoS One 2011 PubMed PDF - The need for a transdisciplinary, global health framework
Picard M, Sabiston C, McNamara JK. J Alt Complement Med 2011 PubMed PDF
Updated: April 2024
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