PREPRINTS

• Mitochondrial and Stress-Related Psychobiological Regulation of FGF21 in Humans
  Kurade M, Bobba-Alves N, Kelly C, Behnke A, Conklin Q, Juster RP, Hirano M, Trumpff C, Picard M. 
  Preprint: https://www.medrxiv.org/content/10.1101/2025.01.30.25321437v1
  
  
• The energetic stress marker GDF15 is induced by acute psychosocial stress
  Huang Q, Monzel AS, Rausser S, Haahr R, Devine J, Liu CC, Kelly C, Thompson E, Kurade M, Michelson J, Shaulson ED, Li S, Engelstad K, Tanji K, Lauriola V, Wang T, Wang S, Zuraikat FM, St-Onge MP, Kaufman BA, Sloan R, Juster RP, Marsland AL, Gouspillou G, Hirano M, Picard M, Trumpff C. 
  Preprint:  www.biorxiv.org/content/10.1101/2024.04.19.590241v4
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• Perceived association of mood and symptom severity in adults with mitochondrial diseases
  Kelly C, Cross M, Junker A, Engelstad K, Rosales X, Hirano M, Trumpff C, Picard M.
  Preprint: www.medrxiv.org/content/10.1101/2024.02.02.24302076v1​

2025

• A human brain map of mitochondrial respiratory capacity and diversity
  Mosharov EV, Rosenberg AM, Monzel AS, Osto CA, Stiles L, Rosoklija GB, Dwork AJ, Bindra S, Junker A, Zhang Y, Fujita M, Mariani MB, Bakalian M, Sulzer D, De Jager PL, Menon V, Shirihai OS, Mann JJ, Underwood M, Boldrini M, Thiebaut de Schotten M, Picard M.  Nature 2025  Link PDF Briefing 

2024

• A platform to map the mind-mitochondria connection and the hallmarks of psychobiology: The MiSBIE Study
  Kelly C, Trumpff C, Acosta C, Assuras S, Baker J, Basarrate S, Behnke A, Bo K, Bobba-Alves N, Champagne FA, Conklin Q, Cross M, De Jager P, Engelstad K, Epel A, Franklin SG, Hirano M, Huang Q, Junker A, Juster RP, Kapri D, Kirschbaum C, Kurade M, Lauriola V, Li S, Liu CC, Liu G, McEwen BS, McGill MA, McIntyre K, Monzel AS, Michelson J, Prather AA, Puterman E, Rosales X, Shapiro PA, Shire D, SlavichGM, Sloan RP, Smith JLM, Spann M, Spicer J, Sturm G, Tepler S, Thiebaut de Schotten M, Wager TD, Picard M, The MiSBIE Study Group.  Trends Endocrinol Metab 2024 Link  PDF  
  
  
• Psychosocial experiences are associated with human brain mitochondrial biology
  Trumpff, C, Monzel A, Sandi C, Menon V, Klein H-U, Fujita M, Lee A, Petyuk VA, Hurst C, Duong DM, Seyfried NT, Wingo AP, Wingo TS, Wang Y, Thambisetty M, Ferrucci L, Bennett DA, De Jager PL, Picard M. PNAS 2024  Link  PDF 
  
  

2023

• Mitochondrial diversity and network organization predict anxiety-like behavior in mice.
  Rosenberg A, Saggar M, Monzel AS, Devine J, Rogu P, Mosharov EV, Junker A, Sandi C, Dumitriu D, Anacker C, Picard M.  Nat Commun 2023  Link  PDF 
  
  

2022​

• Energy transduction and the mind-mitochondria connection
  Picard M. The Biochemist  2022   Link PDF
  
  

2021

• Quantitative mapping of human hair graying and reversal in relation to life stress
  Rosenberg A, Rausser S, Ren J, Mosharov EV, Sturm G, Ogden RT, Patel P, Soni RK, Lacefield C, Tobin DJ, Paus R, Picard M. 
  eLife 2021  PubMed   PDF​   eLife Digest
  
  
• Stress and circulating cell-free mitochondrial DNA: a systematic review of human studies, physiological considerations, and technical recommendations.
  Trumpff C, Michelson J, Lagranha CJ, Taleon V, Karan K, Sturm G, Lindqvist D, Fernström J, Moser D, Kaufman BA, Picard M.
  Mitochondrion 2021  PubMed   PDF​   Protocol
  
  
• Mitochondria in epithelial ovarian carcinoma exhibit abnormal phenotypes and blunted associations with biobehavioral factors
  Bindra S, McGill MA, Triplett MK, Tyagi A, Thaker PH, Dahmoush L, Goodheart MJ, Ogden RT, E Owusu-Ansah, Karan KR, Cole S, Sood AK, Lutgendorf SK, Picard M. Sci Rep 2021  PubMed   PDF​​

​2019

• Mitochondrial psychobiology: Foundation and applications
  Picard M, Trumpff C, Burelle Y. Curr Opin Behav Sci 2019  Link  PDF​
  
  
• Predictors of ccf-mtDNA reactivity to acute psychological stress identified using machine learning classifiers: A proof-of-concept
  Trumpff C, Marsland AL, Sloan RP, Kaufman BK, Picard M. Psychoneuroendocrinol 2019   PubMed   PDF
  
  
• Acute psychological stress increases serum circulating cell-free mitochondrial DNA
  Trumpff C, Marsland AL, Basualto C, Martin JL, Carroll JE, Sturm G, Gu Z, Vincent A, Kaufman BA, Picard M. Psychoneuroendocrinol 2019   PubMed   PDF
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• Accelerating research on biological aging and mental health: Current challenges and future directions
  Han LKM, Verhoeven JE, Tyrka A, Penninx BWJH, Wolkowitz OM, Månsson KNT, Lindqvist D, Vinkers CH, Boks MP, Révész D, Mellon SH, Picard M. Psychoneuroendocrinol 2019   PubMed   PDF​​

2018 and earlier​

• A mitochondrial health index sensitive to mood and caregiver stress
  Picard M, Prather AA, Puterman E, Cuillerier A, Coccia M, Aschbacher K, Burelle Y, Epel ES. Biol Psychiatr 2018   ​PubMed   PDF​
  
  
• Psychological stress and mitochondria: A systematic review (Part I)
  Picard M, McEwen BS. Psychosom Med 2018   PubMed   PDF
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• Psychological stress and mitochondria: A conceptual framework (Part II)
  Picard M, McEwen BS. Psychosom Med 2018   PubMed   PDF
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• Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory and transcriptional responses to psychological stress
  Picard M, McManus MJ, Gray J, Nasca C, Moffat C, Kopinsky P, Seifert E, McEwen BS, Wallace DC. PNAS 2015  PubMed   PDF
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• Mitochondria impact brain function and cognition
  Picard M and McEwen BS. PNAS 2014 [Commentary]   PubMed   PDF
  
  

• Allostatic load as a tool for monitoring comorbidities in schizophrenia and bipolar disorder
  Bizik G, Picard M, Nijjer R, Tourjman V, McEwen BS, Lupien SJ, Juster RP. Harv Rev Neurosci 2013   PubMed   PDF
  
  
• Pathways to aging: The mitochondrion at the intersection of biological and psychosocial sciences
  Picard M. J Aging Res 2011   PubMed   PDF
  
  
• A transdisciplinary perspective of chronic stress in relation to psychopathology throughout lifespan development
  Juster RP, Bizik G, Picard M, Arsenault-Lapierre G, Sindi S, Trepanier L, Marin MF, Wan N, Sekerovic Z, Lord C, Fiocco A, Plusquellec P, McEwen B, Lupien S. Dev Psychopathol 2011   PubMed   PDF