PREPRINTS
  • Mitochondrial and Stress-Related Psychobiological Regulation of FGF21 in Humans
    Kurade M, Bobba-Alves N, Kelly C, Behnke A, Conklin Q, Juster RP, Hirano M, Trumpff C, Picard M. 
    Preprint: https://www.medrxiv.org/content/10.1101/2025.01.30.25321437v1

  • Immune mitochondrial pehonotypes are largely preserved in mitochondrial diseases and do not reflect disease severity
    Liu CC, Kurade M, Monzel AS, Kelly C, Juster RP, Trumpff C, Hirano M, Picard M. 
    Preprint: https://www.biorxiv.org/content/10.1101/2025.01.18.633635v2
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  • The mitochondrial disease biomarker GDF15 is quantifiable in saliva, exhibits dynamic properties and correlates with disease severity
    Huang Q, Trumpff C, Monzel AS, Rausser S, Devine J, Liu CC, Kelly C, Kurade M, Li S, Engelstad K, Tani K, Lauriola V, Wang T, Wang S, Sloan R, Juster RP, Hirano M, Picard M. 
    Preprint: https://osf.io/preprints/osf/m8rwj
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  • Perceived association of mood and symptom severity in adults with mitochondrial diseases
    Kelly C, Cross M, Junker A, Engelstad K, Rosales X, Hirano M, Trumpff C, Picard M.
    Preprint: www.medrxiv.org/content/10.1101/2024.02.02.24302076v1
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  • Accelerated physiology and increased energy expenditure in animals and humans with mitochondrial defects: A meta-analysis
    Sercel A, Sturm G, Shaulson ED, Gallagher D, St-Onge MP, Kempes C, Pontzer H, Hirano M,  Picard M. 
    Preprint: https://www.biorxiv.org/content/10.1101/2023.09.09.556754v1​

2024
  • A platform to map the mind-mitochondria connection and the hallmarks of psychobiology: The MiSBIE Study
    Kelly C, Trumpff C, Acosta C, Assuras S, Baker J, Basarrate S, Behnke A, Bo K, Bobba-Alves N, Champagne FA, Conklin Q, Cross M, De Jager P, Engelstad K, Epel A, Franklin SG, Hirano M, Huang Q, Junker A, Juster RP, Kapri D, Kirschbaum C, Kurade M, Lauriola V, Li S, Liu CC, Liu G, McEwen BS, McGill MA, McIntyre K, Monzel AS, Michelson J, Prather AA, Puterman E, Rosales X, Shapiro PA, Shire D, SlavichGM, Sloan RP, Smith JLM, Spann M, Spicer J, Sturm G, Tepler S, Thiebaut de Schotten M, Wager TD, Picard M, The MiSBIE Study Group.  Trends  Endocrinol Metab 2024 Link  PDF  

2023​
  • OxPhos defects cause hypermetabolism and reduce lifespan in cells and patients with mitochondrial diseases
    Sturm G, Karan KR, Monzel AS, Santhanam BS, Taivassalo T, Bris C, Duplaga SA, Cross M, Towheed A, Higgins-Chen A, McManus MJ, Cardenas A, Lin J, Epel ES, Rahman S, Vissing V, Grassi B, Levine M, Horvath S, Haller RG, Lanaers G, Wallace DC, Tavazoie S, Procaccio V, Kaufman BA, Seifert EL, Hirano H, Picard M. Commun Biol 2023   Link  PDF
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2022
  • A multi-omic and bioenergetics longitudinal aging dataset in primary human fibroblasts with mitochondrial perturbations
    Sturm G, Monzel AS, Karan KR, Michelson J, Ware SA, Cardenas A, Lin J, Bris C, Santhanam B, Murphy MP, Levine ME, Horvath S,
    Belsky D, Wang S, Procaccio V, Kaufman BA, Hirano M, Picard M. Sci Data 2022  Link  PDF
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  • Leukocyte cytokine responses in adult patients with mitochondrial DNA defects
    Karan KR, Trumpff C, Cross M, Englestad KM, Marsland AL, McGuire P, Hirano M, Picard M. J Mol Med  2022   Link  PDF ​

2016 and earlier
  • The spectrum of mitochondrial ultrastructural defects in mitochondrial myopathy
    Vincent AE, Ng YS, White K, Davey T, Mannella C, Falkous G, Feeney C, Schaefer AM, McFarland R, Gorman GS, Taylor RW, 
    Turnbull DM, Picard M. Sci Rep 2016    PubMed   PDF   Suppl
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  • Disentangling (epi)genetic and environmental contributions to the m.3243A>G MELAS mutation phenotype: Phenotypic destiny in mitochondrial disease?
    Picard M, Hirano M. JAMA Neurol 2016   PubMed   PDF
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  • Progressive increase in mtDNA 3243A>G heteroplasmy results in abrupt transcriptional remodeling
    Picard M, Zhang J, Hanecock S, Derbeneva O, Golhar R, Golik P, O’Hearn S, Levy SE, Potluri P, Lvova M, Davila A, Lin CS, Perin JC, Rappaport EF, Hakonarson H, Trounce I, Procaccio V, Wallace DC. PNAS 2014   PubMed   PDF