2025 MiSBIE Symposium at Columbia University | A fabulous and stimulating day distilled into eight minutes
The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study is a NIH-funded research platform allowing investigators to ask deeply interdisciplinary questions around brain-body processes, mitochondrial diseases, and the link between energy and health processes.
This page contains information about the MiSBIE Study including December 2025 MiSBIE Symposium, the MiSBIE mother paper and study material (data dictionary, protocols, etc), and Publications. and Data Requests information (in development, planned summer 2026).
This page contains information about the MiSBIE Study including December 2025 MiSBIE Symposium, the MiSBIE mother paper and study material (data dictionary, protocols, etc), and Publications. and Data Requests information (in development, planned summer 2026).
The 2025 MiSBIE Symposium
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Thanks to everyone who participated and made the 2025 MiSBIE Symposium a success!
With gratitude, Martin, Caroline, and the MiSBIE Team
The 2025 MiSBIE Symposium included >620 registered, participating either in person or virtually.
This momentous event for the MiSBIE team brought people from all domains of life together, ranging from community members and families, physicians, students, entrepreneurs, investors, and academic scientists.
Read more about the science shared from MitoWorld
Symposium Recordings and Slides
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MiSBIE Study rationale and protocol - Martin Picard and Caroline Trumpff
Downloadable Slides |
MitoBrain MRI Map - Michel Thiebaut de Schotten
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Mitochondrial energy transformation capacity influences brain activation during sensory, affective, and cognitive tasks - Ke Bo / Tor Wager
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Immune mitochondrial phenotypes - Jack Devine
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Immune cell bienergetics (seahorse) in mitochondrial diseases - Anna Monzel
Downloadable Slides |
Life adversity moderates the relationship between immune cell mitochondrial respiration and mood symptoms - Cynthia Liu
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Mitochondrial biology and time perception - Darshana Kapri
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Mitochondrial disease and allostatic load - Alex Junker
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The MiSBIE stress reactivity protocol & Physiological and neuroendocrine reactivity in health and mitochondrial disease - Natalia Bobba-Alves
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Saliva and blood cell-free mtDNA reactivity to acute psychosocial stress - David Shire
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FGF21 reactivity to acute psychosocial stress - Mangesh Kurade
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GDF15 reactivity to acute psychosocial stress - Caroline Trumpff
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Novel pipelines to extract differences in proteome dynamics based on health status - Alan Cohen
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The energetic cost of mitochondrial disorders across day and night: MDEE - Evan Shaulson
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Summary: Opportunities, collaborations, data sharing - Martin Picard
Downloadable Slides
Downloadable Slides
The MiSBIE Mother Paper & Resources
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MiSBIE Protocol Summary
Overview of 2-Day MiSBIE Protocol
MiSBIE Data Dictionary
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Detailed MiSBIE Protocol
MiSBIE Questionnaire Packages
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Click to go to the MiSBIE data request form
MiSBIE Transition Meeting
In April 2024, approximately 75 MiSBIE Team members, collaborators, partners, and broader international community members gathered to review the study rationale and design, 2-day protocol, and to share data, preliminary analyses, and some exciting initial results.
This meeting marked the transition from the data collection phase to the analysis and learning phase of the MiSBIE study.
Meeting Agenda
In April 2024, approximately 75 MiSBIE Team members, collaborators, partners, and broader international community members gathered to review the study rationale and design, 2-day protocol, and to share data, preliminary analyses, and some exciting initial results.
This meeting marked the transition from the data collection phase to the analysis and learning phase of the MiSBIE study.
Meeting Agenda
MiSBIE Transition Meeting Slides - April 2024
Mitochondrial Stress Brain Imaging & Epigenetics Study Presentation
A summary, update, and forward-looking discussion among MiSBIE Team members, collaborators, and partners
MiSBIE Publications
PREPRINTS
PUBLISHED
PREPRINTS
- Immune mitochondrial pehonotypes are largely preserved in mitochondrial diseases and do not reflect disease severity
Liu CC, Kurade M, Monzel AS, Kelly C, Juster RP, Trumpff C, Hirano M, Picard M. Preprint
- The energetic stress marker GDF15 is induced by acute psychosocial stress
Huang Q, Monzel AS, Rausser S, Haahr R, Devine J, Liu CC, Kelly C, Thompson E, Kurade M, Michelson J, Shaulson ED, Li S, Engelstad K, Tanji K, Lauriola V, Wang T, Wang S, Zuraikat FM, St-Onge MP, Kaufman BA, Sloan R, Juster RP, Marsland AL, Gouspillou G, Hirano M, Picard M, Trumpff C. Preprint
PUBLISHED
- Mitochondrial and psychosocial stress-related regulation of FGF21 in humans
Kurade M, Bobba-Alves N, Kelly C, Behnke A, Conklin Q, Juster RP, Hirano M, Trumpff C, Picard M. Nat Metab 2025 Link PDF
- Saliva and blood cell-free mtDNA reactivity to acute psychosocial stress
Trumpff C, Shire D, Michelson J, Bobba-Alves N, Yu T, Sloan RP, Juster RP, Hirano M, Picard M. Psychoneuroendocrinology 2025 Link PDF
- A platform to map the mind-mitochondria connection and the hallmarks of psychobiology: The MiSBIE study
Kelly C, Trumpff C, Acosta C, Assuras S, Baker J, Basarrate S, Behnke A, Bo K, Bobba-Alves N, Champagne FA, Conklin Q, Cross M, De Jager P, Engelstad K, Epel A, Franklin SG, Hirano M, Huang Q, Junker A, Juster RP, Kapri D, Kirschbaum C, Kurade M, Lauriola V, Li S, Liu CC, Liu G, McEwen BS, McGill MA, McIntyre K, Monzel AS, Michelson J, Prather AA, Puterman E, Rosales X, Shapiro PA, Shire D, SlavichGM, Sloan RP, Smith JLM, Spann M, Spicer J, Sturm G, Tepler S, Thiebaut de Schotten M, Wager TD, Picard M, The MiSBIE Study Group. Trends in Endocrinology & Metabolism 2024 Link PDF - The mitochondrial disease biomarker GDF15 is quantifiable in saliva, exhibits dynamic properties and correlates with disease severity
Huang Q, Trumpff C, Monzel AS, Rausser S, Devine J, Liu CC, Kelly C, Kurade M, Li S, Engelstad K, Tani K, Lauriola V, Wang T, Wang S, Sloan R, Juster RP, Hirano M, Picard M. Mol Genet Metab 2025 Link PDF
- Leukocyte cytokine responses in adult patients with mitochondrial DNA defects
Karan KR, Trumpff C, Cross M, Englestad KM, Marsland AL, McGuire P, Hirano M, Picard M. J Mol Med 2022 Link PDF
Downloadable MiSBIE study brochure
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The MitoLab and MiSBIE clinical Team
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