The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study is a NIH-funded research platform allowing investigators to ask deeply interdisciplinary questions around brain-body processes, mitochondrial diseases, and the link between energy and health processes.
This page contains information about the MiSBIE Study, including the MiSBIE Transition Meeting video recording, the MiSBIE mother paper and study material (in preparation), Publications using the MiSBIE dataset, and Data Requests information (in development, planned Winter 2025).
The first Annual MiSBIE Symposium will be held in Spring 2025.
This page contains information about the MiSBIE Study, including the MiSBIE Transition Meeting video recording, the MiSBIE mother paper and study material (in preparation), Publications using the MiSBIE dataset, and Data Requests information (in development, planned Winter 2025).
The first Annual MiSBIE Symposium will be held in Spring 2025.
The MiSBIE Mother Paper & Resources
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MiSBIE Protocol Summary
Overview of 2-Day MiSBIE Protocol
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Detailed MiSBIE Protocol
MiSBIE Questionnaire Packages
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MiSBIE Data Dictionary
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MiSBIE Transition Meeting
In April 2024, approximately 75 MiSBIE Team members, collaborators, partners, and broader international community members gathered to review the study rationale and design, 2-day protocol, and to share data, preliminary analyses, and some exciting initial results.
This meeting marked the transition from the data collection phase to the analysis and learning phase of the MiSBIE study.
Meeting Agenda
In April 2024, approximately 75 MiSBIE Team members, collaborators, partners, and broader international community members gathered to review the study rationale and design, 2-day protocol, and to share data, preliminary analyses, and some exciting initial results.
This meeting marked the transition from the data collection phase to the analysis and learning phase of the MiSBIE study.
Meeting Agenda
MiSBIE Transition Meeting Slides - April 2024
Mitochondrial Stress Brain Imaging & Epigenetics Study Presentation
A summary, update, and forward-looking discussion among MiSBIE Team members, collaborators, and partners
MiSBIE Publications
- A platform to map the mind-mitochondria connection and the hallmarks of psychobiology: The MiSBIE Study
Kelly C, Trumpff C, Acosta C, Assuras S, Baker J, Basarrate S, Behnke A, Bo K, Bobba-Alves N, Champagne FA, Conklin Q, Cross M, De Jager P, Engelstad K, Epel A, Franklin SG, Hirano M, Huang Q, Junker A, Juster RP, Kapri D, Kirschbaum C, Kurade M, Lauriola V, Li S, Liu CC, Liu G, McEwen BS, McGill MA, McIntyre K, Monzel AS, Michelson J, Prather AA, Puterman E, Rosales X, Shapiro PA, Shire D, SlavichGM, Sloan RP, Smith JLM, Spann M, Spicer J, Sturm G, Tepler S, Thiebaut de Schotten M, Wager TD, Picard M, The MiSBIE Study Group. Trends in Endocrinology & Metabolism 2024 Link PDF - The mitochondrial disease biomarker GDF15 is quantifiable in saliva, exhibits dynamic properties and correlates with disease severity
Huang Q, Trumpff C, Monzel AS, Rausser S, Devine J, Liu CC, Kelly C, Kurade M, Li S, Engelstad K, Tani K, Lauriola V, Wang T, Wang S, Sloan R, Juster RP, Hirano M, Picard M.
Preprint: https://osf.io/preprints/osf/m8rwj - The energetic stress marker GDF15 is induced by acute psychosocial stress
Huang Q, Monzel AS, Rausser S, Haahr R, Devine J, Liu CC, Kelly C, Thompson E, Kurade M, Michelson J, Shaulson ED, Li S, Engelstad K, Tanji K, Lauriola V, Wang T, Wang S, Zuraikat FM, St-Onge MP, Kaufman BA, Sloan R, Juster RP, Marsland AL, Gouspillou G, Hirano M, Picard M, Trumpff C.
Preprint: www.biorxiv.org/content/10.1101/2024.04.19.590241v4
- Leukocyte cytokine responses in adult patients with mitochondrial DNA defects
Karan KR, Trumpff C, Cross M, Englestad KM, Marsland AL, McGuire P, Hirano M, Picard M. J Mol Med 2022 Link PDF
Downloadable MiSBIE study brochure
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The MitoLab and MiSBIE clinical Team
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